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Toxicology and applied pharmacology

Toxicology and applied pharmacology

IF: 3.29
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Effect of 1,4-dibromobenzene and 1,2,4-tribromobenzene on xenobiotic metabolism

Published:1 October 1977 DOI: 10.1016/0041-008X(77)90209-5 PMID: 929601
Gary P. Carlson , Robert G. Tardiff

Abstract

1,4-Dibromobenzene and 1,2,4-tribromobenzene were administered po to male rats for 45 and 90 days, with or without a 30-day recovery period. After 45 or 90 days of administration, both 1,4-dibromobenzene (10 and 20 mg/kg) and 1,2,4-tribromobenzene (2.5, 5, and 10 mg/kg) increased liver to body weight ratios, cytochrome P-450 content, EPN detoxification, and azoreductase activity. In addition, 1,2,4-tribromobenzene, which was the more potent inducer, increased NADPH-cytochrome c reductase activity and benzpyrene hydroxylase activity. Glucuronyltransferase activity was not increased by either compound. These effects were not found following the 30-day recovery period. It is concluded that both of these simple brominated benzenes can induce the metabolism of xenobiotics but that the effects are not prolonged following the cessation of administration of the compounds.

Substances (5)

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Procduct Name CAS Molecular Formula Supplier Price
1,4-Dibromobenzene 106-37-6 C6H4Br2 577 suppliers $9.00-$1025.00
1,3,5-Tribromobenzene 626-39-1 C6H3Br3 555 suppliers $5.00-$769.05
1,2,4-TRIBROMOBENZENE 615-54-3 C6H3Br3 139 suppliers $13.00-$1255.00
dibromobenzene 26249-12-7 C6H4Br2 2 suppliers Inquiry
tribromobenzene 28779-08-0 C6H3Br3 - Inquiry

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