Description

The chemical name of adenosine triphosphate disodium (ATP disodium salt） is adenosine nucleoside-5'-triphosphate disodium salt, the molecular formula is C10H17N5NaO13P3, and the molecular weight is 531.18.

Biological function

This substance is a coenzyme that can improve body metabolism and participate in the body's metabolism of fat, protein, sugar, nucleic acid, and nucleotides. It is also the primary source of energy in the body. When the body absorbs secretes, muscle contracts and performs biochemical processes. When energy is required for synthesis reactions, etc., adenosine triphosphate disodium is decomposed into adenosine diphosphate disodium and phosphate groups, and energy is released at the same time[1].

Mechanism of action

Animal experiments have shown that this drug can inhibit the slow calcium ion influx of slow-responsive fibers, block or delay the forward conduction in the atrioventricular node reentry pathway, and large doses may also block or delay the forward and retrograde conduction of the accessory pathway; In addition, it also has the effect of temporarily strengthening the vagus nerve, thus terminating arrhythmias caused by atrioventricular node reentry and accessory pathway reentry mechanisms.

The raw materials and injection solutions of adenosine disodium triphosphate have been included in the second volume of the 2010 edition of the Chinese Pharmacopoeia. Adenosine triphosphate disodium is a high-energy phosphoric acid compound that is extremely unstable to heat and quickly decomposes to produce adenosine diphosphate disodium, adenosine sodium monophosphate, and phosphoric acid. It also releases energy. Therefore, stabilizers need to be added to existing injection production. Inhibit degradation reactions.

References

[1] TY Shan, et al. CN102697712A, (2012)