Lidocaine synthesis
Jul 30,2024
Lidocaine also called lidopen, xylocaine, xylocard, is a prototype of antiarrhythmic drugs of subgroup IB, and is a sodium channel blocker (class 1B antiarrhythmic) that causes a depression of rapidly depolarizing tissue. It can be used as a local anesthetic and as an antiarrhythmic after heart attacks. It has also found use in asthma therapy (dispensed in nebulizers).
Lidocaine is usually administered intravenously for short-term therapy of ventricular extrasystole, tachycardia, especially in the severe phase of myocardial infarction, arrhythmia of natural cause, and for arrhythmia that can originate in the heart during surgical manipulations.
A method for preparing lidocaine: using 2,6-dimethylaniline and chloroacetic chloride as raw materials to prepare an intermediate, namely acetyl chloride-2,6-dimethylaniline, and using the prepared intermediate and diethylamine to react and obtain lidocaine, wherein acetone is used as solvent and carbonate is used as catalyst in thereaction process.
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