AMG-510是有效的KRAS G12C共價(jià)抑制劑,具有潛在的抗腫瘤活性。該AMG510是手性化合物。
IN VIVO: In preclinical tumor models, AMG-510 rapidly and irreversibly binds to KRAS G12C, providing durable suppression of the mitogen-activated protein kinase (MAPK) signaling pathway. AMG-510 (orally; once daily) is capable of inducing tumor regression in mouse models of KRAS G12C cancer[3].
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