Entrectinib, also known as RXDX-101 and NMS-E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity. RXDX-101 has demonstrated potent pharmacological activity in preclinical studies and has the potential to be first-in-class against the Trk family of kinases. PXDX-101 has been well tolerated in patients with advanced solid tumors.
Properties:
Density: 1.053g/cm3
Boiling Point: 431.2ºC at 760mmHg
Flash Point: 183.9ºC
Refractive Index: 1.524
Storage Condition: Store at RT
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crene
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