Bifunctional Chimeras of Glutamylcysteine Synthetase and Glutathione Synthetase (Crude Enzyme)

Bifunctional Chimeras of Glutamylcysteine Synthetase and Glutathione Synthetase，中文名為谷氨酰半胱氨酸合成/谷胱甘肽合成雙功能酶。本產(chǎn)品為大腸桿菌表達的谷氨酰半胱氨酸合成/谷胱甘肽合成雙功能酶，并經(jīng)簡單純化獲得的可以確保達到一定酶活力的粗酶液。
由于本產(chǎn)品需新鮮制備，確認訂購后約6個工作日才可以發(fā)貨。個別情況首次制備出現(xiàn)問題，發(fā)貨時間會順延。
本產(chǎn)品可以提供十公斤、百公斤乃至噸級的粗酶液，如有需求請聯(lián)系康朗。
GSH, and by extension GCL, is critical to cell survival. Nearly every eukaryotic cell, from plants to yeast to humans, expresses a form of the GCL protein for the purpose of synthesizing GSH. To further highlight the critical nature of this enzyme, genetic knockdown of GCL results in embryonic lethality. Furthermore, dysregulation of GCL enzymatic function and activity is known to be involved in the vast majority of human diseases, such as diabetes, Parkinson's disease, Alzheimers disease, COPD, HIV/AIDS, and cancer. This typically involves impaired function leading to decreased GSH biosynthesis, reduced cellular antioxidant capacity, and the induction of oxidative stress. However, in cancer, GCL expression and activity is enhanced, which serves to both support the high level of cell proliferation and confer resistance to many chemotherapeutic agents.Glutathione synthase belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). This product with the indicated enzyme activity was briefly purified from engineered E.coli.
產(chǎn)品詳細信息見下表:

包裝清單：

保存條件：
-20℃或更低溫度保存，至少1個月有效。
注意事項：
由于本產(chǎn)品需新鮮制備，在您確認訂購后約6個工作日才能發(fā)貨。個別情況首次制備出現(xiàn)問題，發(fā)貨時間會順延。
粗酶液的每次凍融均可能會引起部分失活，所以收到酶液后請根據(jù)需要進行分裝，并置于-20℃或更低溫度保存。
隨著保存時間的延長，酶活力會有一定程度的下降，收到產(chǎn)品后應盡快使用。
本產(chǎn)品在生產(chǎn)和保存的過程中可能會有混濁或沉淀產(chǎn)生，融化后混勻即可，不影響正常使用。
本產(chǎn)品僅限于專業(yè)人員的科學研究用，不得用于臨床診斷或治療，不得用于食品或藥品，不得存放于普通住宅內(nèi)。
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