Anti-CBS antibodyCat. No. ?? ?JC221789
Package?? ?25 μl/100 μl/200 μl
Storage?? ?-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Product overviewDescription ? ? ? ? ? ? ? ?? ?Anti-CBS rabbit polyclonal antibody
Applications ? ??? ?ELISA, WB, IHC?
Immunogen ? ? ? ? ? ?? ?Fusion protein of human CBS
Reactivity ? ? ? ? ? ? ?? ?Human, Mouse, Rat
Content ? ? ? ? ? ? ? ? ?? ?0.2 mg/ml
Host species ? ? ? ? ? ?? ?Rabbit
Ig class ? ? ? ? ? ? ??? ?Immunogen-specific rabbit IgG
Purification ? ? ? ? ? ? ?? ?Antigen affinity purification
Target informationSymbol ? ? ? ? ? ? ?? ?CBS
Full name ? ? ? ? ? ? ?? ?cystathionine-beta-synthase
Synonyms?? ?HIP4
Swissprot?? ?P35520
Target BackgroundThe protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene.
ApplicationsImmunohistochemistry
Predicted cell location: Cytoplasm
Positive control: Human liver cancer
Recommended dilution: 25-100?? ?
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