Species

Gene ID

Accession

Source

Length

MW

Tag

Rat

301289

G3V7M4

E. coli

133aa

30kDa

－

About this Antibody

Name

Recombinant Rat IL-17A (Recombinant Rat Interleukin-17A; rRtIL-17A)；重組大鼠白細(xì)胞介素17A

Synonyms

CTLA-8; IL17A; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A

Purity

>95% by SDS-PAGE and HPLC analyses.

Biological Activity

Fully biologically active when compared to standard. The ED50 as determined by inducing IL-6 secretion of murine NIH/3T3 cells is less than 1.0ng/ml, corresponding to a specific activity of >1.0×10⁶IU/mg.

Physical Appearance

Sterile Filtered White lyophilized (freeze-dried) powder.

Formulation

Lyophilized from a 0.2μm filtered concentrated solution in 2X PBS, pH6.5.

Endotoxin

Less than 0.1EU/μg of rRtIL-17A as determined by LAL method.

Reconstitution

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Reconstitute in 4mM HCl to a concentration of 0.1-1.0mg/ml. Stock solutions should be apportioned into working aliquots and stored at ≤-20℃. Further dilutions should be made in appropriate buffered solutions.

Category

Cytokine

Background

IL-17A, also named CTLA8 and IL17, is belonging to the IL-17 family and is encoded by the IL-17A gene in humans. The IL-17 family is comprised of at least six proinflammatory cytokines that share a conserved cysteine-knot structure but diverge at the N-terminus. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases, and can stimulate the expression of IL-6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17 family members are glycoproteins secreted as dimers that induce local cytokine production and recruit granulocytes to sites of inflammation.

Amino Acid Sequence

AVLIPQSSVC PNAEANNFLQ NVKVNLKVIN SLSSKASSRR PSDYLNRSTS PWTLSRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPEKCPFT FRVEKMLVGV GCTCVSSIVR HAS

產(chǎn)品編號(hào)

產(chǎn)品名稱

包裝

P6303-5μg

Recombinant Rat IL-17A

5μg

P6303-25μg

Recombinant Rat IL-17A

25μg

P6303-100μg

Recombinant Rat IL-17A

100μg

P6303-1mg

Recombinant Rat IL-17A

1mg

-

說明書

1份