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Fmoc-D-His(Bzl)-OH,Fmoc-D-His(Bzl)-OH
  • Fmoc-D-His(Bzl)-OH,Fmoc-D-His(Bzl)-OH

Fmoc-D-His(Bzl)-OH

價(jià)格 500
包裝 500MG
最小起訂量 500MG
發(fā)貨地 上海
更新日期 2022-07-14

產(chǎn)品詳情

中文名稱:Fmoc-D-His(Bzl)-OH英文名稱:Fmoc-D-His(Bzl)-OH
CAS:2022956-32-5產(chǎn)品類別: 氨基酸衍生物
2022-07-14 Fmoc-D-His(Bzl)-OH Fmoc-D-His(Bzl)-OH 500MG/500RMB 500 氨基酸衍生物

Product name: Fmoc-D-His(1-Bzl)-OH

Synonym: Fmoc-D-His(Bzl)-OH, Nalpha-Fmoc-Nim-benzyl-D-histidine, (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1-benzyl-1H-imidazol-4-yl)propanoic acid,

Catalog #: 8217007

Purity: 95%

CAS No.:

Molecular Formula: C28H25N3O4

Molecular Weight: 467.53

Compound ID:

Description: The influence of gonadotrophin-releasing hormone (GnRH) and its analogues (i.e., agonist and antagonist) on vasopressin (VP) release from the rat hypothalamo-neurohypophysial (H-N) system was studied both in vitro and in vivo. Additionally, it was determined whether the possible response of vasopressinergic neurones to these peptides could be modified by melatonin through a cAMP-dependent mechanism. In this study we demonstrate, for the first time, that the highly selective GnRH agonist (i.e., [Des-Gly(10),D-His(Bzl)(6),Pro-NHEt(9)]-LHRH; histrelin) stimulates the release of VP from the rat H-N system, while native GnRH and its antagonist remain inactive in modifying this process in vitro. Melatonin significantly inhibited basal and histrelin-induced release of VP in vitro, but displayed no significant influence on VP secretion when GnRH or its antagonist were present in a medium. Melatonin fully suppressed forskolin-stimulated VP release from the rat H-N system. On the other hand, addition of forskolin to a medium containing both histrelin and melatonin did not further alter the inhibitory influence of melatonin on the histrelin-dependent release of VP in vitro. After intracerebroventricular (i.c.v.) infusion of native GnRH or its agonist, blood plasma VP concentration was significantly higher than in control animals, which was accompanied by decreased content of the hormone in the neurohypophysis. Intravenous (i.v.) injection of melatonin did not change, in any subgroup, blood plasma VP concentration, when compared to the vehicle-injected rats. However, the neurohypophysial levels of the hormone were significantly higher after melatonin injection in control, GnRH- and histrelin-infused animals. Our present results suggest that activation of the GnRH receptor in the hypothalamus is involved in stimulation of VP secretion from the rat H-N system. We have also shown that melatonin, at a concentration close to its physiological level in the blood, significantly reduces the in vitro response of vasopressinergic neurones to a GnRH agonist – histrelin; this effect of melatonin could be mediated through intracellular processes that involve, among others, the cAMP-dependent mechanism.

API: Histrelin

關(guān)鍵字: Fmoc-D-His(Bzl)-OH

公司簡介

燊肽科技致力于為國內(nèi)醫(yī)藥研發(fā)機(jī)構(gòu)和科研院校提供多肽和氨基酸衍生物相關(guān)生化試劑, 以及定制合成技術(shù)服務(wù). 我們的產(chǎn)品線包含各種高端進(jìn)口品牌,以及價(jià)格適中的國內(nèi)自主品牌. 我們保證多肽實(shí)驗(yàn)活性和質(zhì)量, 提供24小時(shí)技術(shù)支持.A full-service company dedicated to provide qualified peptide related chemicals, proteins and enabling technologies for scientific research. We are serving over 100 customers over North America, Europe , Japan, Korea, Australia Russia, and Latin America. The comprehensive services which assist you on peptides, intermediates manufacturing from the very beginning of pharma research to large
成立日期 2015-04-10 (10年) 注冊(cè)資本 100萬
員工人數(shù) 1-10人 年?duì)I業(yè)額 ¥ 300萬-500萬
主營行業(yè) 中間體,化學(xué)試劑,技術(shù)服務(wù) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • 燊肽科技(上海)有限公司
非會(huì)員
  • 公司成立:10年
  • 注冊(cè)資本:100萬
  • 企業(yè)類型:貿(mào)易
  • 主營產(chǎn)品:氨基酸衍生物, 多肽及其鏈接劑, PEG以及多肽化學(xué)合成服務(wù)
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