Human JAB1 / COPS5 Protein, Fc Tag

分子別名（Synonym）

JAB1,COPS5

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human JAB1 Protein, Fc Tag (JA1-H5553) is expressed from Baculovirus-Insect cells. It contains AA Ala 2 - Ser 334 (Accession # Q92905-1).

Predicted N-terminus: Ala 2

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 63.9 kDa. The protein migrates as 33 kDa and 64-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

Jab1，也稱為CSN5，是（COP9）信號(hào)體復(fù)合體（CSN）的一個(gè)組成部分，據(jù)報(bào)道參與細(xì)胞增殖、細(xì)胞周期進(jìn)程和腫瘤發(fā)生的調(diào)節(jié)。作為COP9信號(hào)體復(fù)合體的一個(gè)組成部分，Jab1可以相互調(diào)節(jié)MED1的穩(wěn)定性和轉(zhuǎn)錄活性，可能是介導(dǎo)HER2+腫瘤侵襲性表型的MED1直接靶基因。