ProS1產(chǎn)品信息

英文名稱：Prostate-specific antigen

中文名稱：前列腺特異性抗原

靶點(diǎn)別稱：ProS1

物種：Human

標(biāo)簽：His Tag

屬性：Protein

標(biāo)記：Unconjugated

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human ProS1 Protein, His Tag (PR1-H52H3) is expressed from human 293 cells (HEK293). It contains AA Val 284 - Ser 676 (Accession # P07225).

Predicted N-terminus: Val 284

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 45.6 kDa. The protein migrates as 53-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

ProS1是白細(xì)胞免疫球蛋白樣受體（LIR）家族的成員，該家族存在于染色體區(qū)域19q13.4的基因簇中。編碼的蛋白質(zhì)屬于LIR受體的B亞家族，其包含兩個(gè)或四個(gè)細(xì)胞外免疫球蛋白結(jié)構(gòu)域、一個(gè)跨膜結(jié)構(gòu)域和兩到四個(gè)基于細(xì)胞質(zhì)免疫受體酪氨酸的抑制基序（ITIM）。受體在免疫細(xì)胞上表達(dá)，與抗原呈遞細(xì)胞上的MHC I類分子結(jié)合，并傳遞抑制免疫反應(yīng)刺激的負(fù)信號(hào)。它被認(rèn)為可以控制炎癥反應(yīng)和細(xì)胞毒性，以幫助集中免疫反應(yīng)并限制自身反應(yīng)性。已發(fā)現(xiàn)該基因存在編碼不同異構(gòu)體的多種轉(zhuǎn)錄變體。