體外活性 | BAY-7598 inhibits human MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP13, MMP14, and MMP16 (IC50s: 44, 360, 600, 15, 460, 12, 67, 250, and 940 nM). BAY-7598 inhibits murine MMP2, MMP3, MMP7, MMP8, and MMP9 (IC50s: 45, 270, 130, 54, and 210 nM). BAY-7598 inhibits rat MMP2, MMP8, and MMP9 (IC50s: 45, 67, and 1000 nM). |