成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

化合物 CA224,CA224
  • 化合物 CA224,CA224

化合物 CA224|T61266|TargetMol

價(jià)格 1670 2860 7560
包裝 2mg 5mg 25mg
最小起訂量 1mg
發(fā)貨地 上海
更新日期 2024-09-29
QQ交談 微信洽談

產(chǎn)品詳情

中文名稱:化合物 CA224英文名稱:CA224
CAS:883561-04-4品牌: TargetMol
產(chǎn)地: 美國保存條件: Shipping with blue ice.
產(chǎn)品類別: 抑制劑
貨號: T61266
2024-09-29 化合物 CA224 CA224 2mg/1670RMB;5mg/2860RMB;25mg/7560RMB 1670 TargetMol 美國 Shipping with blue ice. 抑制劑

Product Introduction

Bioactivity

名稱CA224
描述CA224 (Compound 1), an orally active and selective Cdk4–cyclin D1 inhibitor, demonstrates an IC50 of 6.2 μM. It induces cell apoptosis and exhibits antitumor activity [1].
體外活性CA224 (Compound 1) (48 h) shows antiproliferation activity against human cancer cell lines [1]. CA224 (18-48 h) blocks the growth of cancer cells at G0/G1 and G2/M phase of the cell cycle, and selectively kills SV40 large T-antigen transformed normal mouse embryonic liver cells (BNL SV A.8) [1] [2]. CA224 (0-4 μM, 30 min) inhibits tubulin polymerization and enhances the depolymerization of stabilized tubulin protein [1]. CA224 (0-72 h) induces cell apoptosis in cancer cells [1]. CA224 (10 μM) shows 50%, 14%, 51% and 19% inhibition of CYP3A4, CYP2D6, CYP2C9, and CYP2C19, respectively [1]. Cell Proliferation Assay [1] Cell Line: LS174T, PC-3, MiaPaCa, A549, Calu-1, NCI-H460, NCI-H1299, NCI-H358, BNL CL2 and BNL SV A.8 Concentration: Incubation Time: 48 h Result: Showed antiproliferation activity with IC 50 values of 3.5, 6.2, 4.0, 3.5, 11.5, 2.0, 2.5, 2.2, 2.6 and 3.8 uM against LS174T, PC-3, MiaPaCa, A549, Calu-1, NCI-H460, NCI-H1299, NCI-H358, BNL CL2 and BNL SV A.8, respectively. Cell Cycle Analysis [1] [2] Cell Line: A549, NCI-H1299, NCI-H358, BNL CL2, BNL SV A.8 and Calu-1 Concentration: IC 50 concentration (IC 70 for Calu-1) Incubation Time: 24 h for A549, NCI-H1299 and Calu-1, 18 h for NCI-H358, 48 h for BNL CL2 and BNL SV A.8 Result: Induced a profound block at G2/M in A549 and NCI-H1299 cells. Maintained nocodazole- and paclitaxel-induced G2/M block in NCI-H358 cells. Exhibited prominent G2/M arrest in BNL CL2 cells. 31% of cells were detected in sub-G1 phase (control: 0%) in BNL SV A.8 cells. Retained the G0/G1 block in serum-starved p53-null Calu-1 cells. Western Blot Analysis [1] Cell Line: A549 and LS174T Concentration: IC 50 concentration; 1, 2, 3 and 4 μM for tubulin polymerization Incubation Time: 24 h; 30 min for tubulin polymerization in A549 cells Result: Induced p53, p21, and p27. Downregulated cyclin B1 and Cdk1. Inhibited tubulin polymerization in a dose-dependent manner and resulted in accumulation of unassembled tubulin in the supernatant. Apoptosis Analysis [1] Cell Line: A549, NCI-H460, NCI-H358, and NCI-H1299 Concentration: IC 50 and IC 70 concentration Incubation Time: 24, 48 and 72 h Result: Induces apoptotic cell death in a dose- and time-dependent manner.
體內(nèi)活性CA224 (Compound 1) (100 mg/kg; i.p.; once a day for 9 days) shows significant tumor growth inhibition without obvious toxicity [1]. Animal Model: The severe combined immunodeficient (SCID) mouse, lacking both T and B immune cells. Male mice weighing 18 25 g, 6 8 weeks of age for subcutaneous injection of HCT-116, female mice weighing 15 24 g, 6 8 weeks of age for subcutaneous injection of NCI-H460 [1] Dosage: 100 mg/kg Administration: Intraperitoneal injection, once a day for 9 consecutive days Result: Showed significant tumor growth inhibition in both HCT-116 and NCI-H460 tumor models without significant bodyweight loss. Animal Model: BALB/c mice [1] Dosage: 10 mg/kg (oral administration) or 1.0 mg/kg (intravenous injection) Administration: Oral or intravenous injection (Pharmacokinetics Analysis) Result: Pharmacokinetics parameters determined for CA224 after IV and PO administration [1]. Parameter IV (1 mg/kg) Oral (10 mg/kg) t 1/2,β (h) 0.33 1.16 AUC 0-t (ng·h/mL) 187 172 AUC 0-∞ (ng·h/mL) 189 182 C max (ng/mL) 371 190 V d (L/Kg) 2.52 nd V dss (L/Kg) 1.76 nd CL (mL/min/kg) 88.3 nd Bioavailability - 9.6% Time points considered for t 1/2,β calculation 0.5-2 h 1-4 h
存儲條件Shipping with blue ice.
關(guān)鍵字: CA224|TargetMol

公司簡介

TargetMol Chemicals Inc. 總部位于馬薩諸塞州波士頓,致力于為全球生化領(lǐng)域科學(xué)家的研究提供專業(yè)的產(chǎn)品和服務(wù)。TargetMol?品牌的客戶群分布于40多個(gè)國家和地區(qū),已發(fā)展成為全球知名的化合物庫和小分子化合物研究供應(yīng)商。 TargetMol?可提供160多種滿足不同需求的化合物庫,以及多種類型的生化試劑產(chǎn)品,包括12000多種抑制劑、16000多種天然產(chǎn)物和各類多肽、抗體、生命科學(xué)試劑盒等,此外,我們還建設(shè)有CADD(計(jì)算機(jī)輔助藥物設(shè)計(jì))研究中心、藥理實(shí)驗(yàn)室、藥化合成平臺三大技術(shù)中心,全方位滿足客戶的定制需求。 憑借我們優(yōu)質(zhì)的產(chǎn)品和服務(wù)、快速高效的全球供應(yīng)鏈和專業(yè)的技術(shù)支持,我們將有效幫助您縮短研發(fā)周期,取得更成功的結(jié)果。
成立日期 2013-04-18 (12年) 注冊資本 589.8595萬人民幣
員工人數(shù) 100-500人 年?duì)I業(yè)額 ¥ 1億以上
主營行業(yè) 中間體,天然產(chǎn)物,生物化工,化學(xué)試劑,生物技術(shù)服務(wù) 經(jīng)營模式 貿(mào)易,工廠,試劑,定制,服務(wù)
  • TargetMol中國(陶術(shù)生物)
VIP 1年
  • 公司成立:12年
  • 注冊資本:589.8595萬人民幣
  • 企業(yè)類型:有限責(zé)任公司(自然人投資或控股)
  • 主營產(chǎn)品:抑制劑&激動劑,天然產(chǎn)物,重組蛋白,化合物庫,技術(shù)服務(wù)
  • 公司地址:上海市靜安區(qū)江場三路238號8樓
詢盤

化合物 CA224|T61266|TargetMol相關(guān)廠家報(bào)價(jià)

產(chǎn)品名稱 價(jià)格   公司名稱 報(bào)價(jià)日期
詢價(jià)
VIP1年
青島愷潤生物醫(yī)藥科技有限公司
2024-11-02
¥198
VIP12年
上海陶術(shù)生物科技有限公司
2024-10-18
詢價(jià)
VIP1年
廣州佳途科技股份有限公司
2024-10-23
內(nèi)容聲明:
以上所展示的信息由商家自行提供,內(nèi)容的真實(shí)性、準(zhǔn)確性和合法性由發(fā)布商家負(fù)責(zé)。 商家發(fā)布價(jià)格指該商品的參考價(jià)格,并非原價(jià),該價(jià)格可能隨著市場變化,或是由于您購買數(shù)量不同或所選規(guī)格不同而發(fā)生變化。最終成交價(jià)格,請咨詢商家,以實(shí)際成交價(jià)格為準(zhǔn)。請意識到互聯(lián)網(wǎng)交易中的風(fēng)險(xiǎn)是客觀存在的