Mouse Fc gamma RIIB / CD32b Protein, His Tag (SPR & BLI & MALS verified)
分子別名(Synonym)
FCGR2B,CD32b
表達區(qū)間及表達系統(tǒng)(Source)
Mouse CD32b, His Tag (CDB-M52H7) is expressed from human 293 cells (HEK293). It contains AA Thr 40 - Arg 217 (Accession # NP_001070657.1).
Predicted N-terminus: Thr 40
蛋白結構(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 22.2 kDa. The protein migrates as 32-42 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
IgG Fc區(qū)受體(FcγR)是Ig超家族的成員,在激活或抑制免疫反應中發(fā)揮作用。識別出三類人FcγRs:RI(CD64)、RII(CD32)和RIII(CD16),它們產生多種亞型。
人類FcγRII/CD32有三個基因(A、B和C),小鼠FcγRII B有一個基因(CD32B)。CD32是IgG的低親和力受體。低親和力免疫球蛋白γFc區(qū)受體II-b(FCGR2B)也稱為CD32b、FCG2、IGFR2。CD32B在B細胞和髓樣樹突狀細胞上表達。B細胞上CD32B的連接下調了抗體的產生,在某些情況下可能會促進細胞凋亡。樹突狀細胞上CD32B的共連接抑制成熟并阻斷細胞活化。CD32B也可能是惡性腫瘤單克隆抗體治療的靶點。
關鍵字: FCGR2B;FCGR2B蛋白;CD32b蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。