鹽酸環(huán)胞苷|T1591|TargetMol

價(jià)格	￥417	￥148	￥232
包裝	200mg	50mg	100mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱(chēng):鹽酸環(huán)胞苷	英文名稱(chēng):Ancitabine hydrochloride
CAS:10212-25-6	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.37%	產(chǎn)品類(lèi)別: 抑制劑
貨號(hào): T1591

Product Introduction

Bioactivity

名稱(chēng)	Ancitabine hydrochloride
描述	Ancitabine hydrochloride (NSC 145668 HCl) is the hydrochloride salt of a cytarabine congener prodrug with antineoplastic activity. Upon administration, ancitabine is slowly hydrolyzed into cytarabine. Subsequently, cytarabine is converted to the triphosphate form within the cell and then competes with cytidine for incorporation into DNA. Because the arabinose sugar sterically hinders the rotation of the molecule within DNA, DNA replication ceases, specifically during the S phase of the cell cycle. Cytarabine agent also inhibits DNA polymerase, resulting in a decrease in DNA replication and repair. Compared to cytarabine, a more prolonged, consistent cytarabine-mediated therapeutic effect may be achieved with ancitabine because of the slow hydrolytic conversion of ancitabine to cytarabine.
激酶實(shí)驗(yàn)	Human placental aromatase activity: The assay is performed in a total volume of 1 mL at 37 ℃. Unless otherwise noted, the incubation mixture contains 11 nM [4- 14C] androstene-3, 17-dione ([4- 14C]A), 24 mM NADPH (tetrasodium salt Type III), the appropriate concentrations of the desired inhibitor, and 120 μg of microsomal protein. The (4- 14C)A is added as a solution in 1.7% ethanol in 0.05 M potassium phosphate buffer (pH 7.4), so that the final concentration of ethanol does not exceed 0.02% (v/v). The reaction is started by the addition of enzyme and stopped after 20 min by the addition of 7 vol of ethyl acetate. The mixture is agitated on a vortex mixer and centrifuged at 600 g for 5 min. The aqueous phase is re-extracted with 7 vol of ethyl acetate, and the combined extracts are evaporated to dryness using an Evapo-Mix. Over 99% of the radio- active of [4- 14C] added is recovered using this extraction system. The residue obtained is dissolved in 150 μL acetone, and 100 μL aliquots are chromatographed for 65 min on thin-layer plates precoated with silica gel 60 using ethyl: acetate: isooctane (140:60, v/v; system A) or toluene: chloroform: methanol (70:140:20; system B). The radioactive zones of the plate are located with a Berthold LB 2760 thin-layer scanner. The radioactive estradiol (E2) and estrone (E1) neaks are identified by comparison with authentic standards. The corresponding bonding band of silica gel is transferred to vials containing 10 mL of scintillation fluid, and counted with a 6880 Liquid Scintillation system.
體外活性	作為一種有效的免疫抑制劑,抗病毒和抗腫瘤劑,Cyclocytidine可用于白血病治療.其需要用不同的復(fù)合注射方法才可發(fā)揮最大抑制效果.
體內(nèi)活性	Cyclocytidine對(duì)需要DNA復(fù)制和處于有絲分裂快速分裂期的細(xì)胞作用最為明顯。Cyclocytidine對(duì)DNA合成所需的DNA和RNA聚合酶以及核苷酸還原酶有也抑制作用。與人類(lèi)的脫氧核苷結(jié)構(gòu)相似,Cyclocytidine HCl (Ancitabine)整合到人類(lèi)的DNA以殺死細(xì)胞,是Cytarabine的前體藥物。
存儲(chǔ)條件	store under nitrogen \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	Ethanol : < 1 mg/mL (insoluble or slightly soluble) DMSO : 10 mg/mL (38.22 mM) H2O : 40 mg/mL (152.9 mM)
關(guān)鍵字	Cyclo-CMP Hydrochloride \| Ancitabine hydrochloride \| Ancitabine Hydrochloride \| Ancitabine \| Autophagy \| inhibit \| CMV \| Inhibitor \| Cyclocytidine \| Cyclocytidine Hydrochloride \| Cytomegalovirus \| Cyclo-CMP
相關(guān)產(chǎn)品	Guanidine hydrochloride \| Naringin \| Valproic Acid \| Taurine \| Gefitinib \| Aceglutamide \| Hydroxychloroquine \| Curcumin \| Stavudine \| Thymidine \| Paeonol \| Sodium 4-phenylbutyrate
相關(guān)庫(kù)	抗癌活性化合物庫(kù) \| 抗癌上市藥物庫(kù) \| 經(jīng)典已知活性庫(kù) \| 已知活性化合物庫(kù) \| 肝臟毒性化合物庫(kù) \| 抗衰老化合物庫(kù) \| 抗病毒庫(kù) \| 藥物功能重定位化合物庫(kù) \| 抗癌藥物庫(kù) \| 毒性化合物庫(kù)

關(guān)鍵字：鹽酸環(huán)胞苷|||NSC 145668 HCl|||Cyclocytidine hydrochloride|||Cyclocytidine HCl|||Cyclo-CMP hydrochloride|||Cyclo-C|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專(zhuān)業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷(xiāo)售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過(guò)在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過(guò)五百家學(xué)校和各類(lèi)企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊(cè)資本：566.2651萬(wàn)人民幣
企業(yè)類(lèi)型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫(kù)，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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