Mouse IL-2 R beta Protein, His Tag

分子別名（Synonym）

IL2RB,RP5-1170K4.6,CD122,P70-75

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Mouse IL-2 R beta, His Tag (ILA-M52H5) is expressed from human 293 cells (HEK293). It contains AA Ala 27 - Glu 240 (Accession # P16297-1).

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a polyhistidine tag at the C-terminus.

The protein has a calculated MW of 27.1 kDa. The protein migrates as 42-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

白細(xì)胞介素-2受體（IL-2R）是一種異三聚體蛋白，在某些免疫細(xì)胞（如淋巴細(xì)胞）的表面表達(dá)，結(jié)合并響應(yīng)稱為IL-2的細(xì)胞因子。IL-2R由3個亞基-α（CD25）、β（CD122）和γ（CD132）-非共價結(jié)合組成。α鏈和β鏈參與結(jié)合IL-2，而細(xì)胞因子相互作用后的信號轉(zhuǎn)導(dǎo)由γ鏈和β亞基進(jìn)行。

CD122也被稱為IL2Rβ，是I型細(xì)胞因子受體家族的成員。CD122是白細(xì)胞介素-2的受體，參與受體介導(dǎo)的內(nèi)吞作用，并轉(zhuǎn)導(dǎo)IL2的促有絲分裂信號。