Mouse IL-6 Protein, His Tag
分子別名(Synonym)
IL6,Interleukin-6,BSF2,HSF,IFNB2
表達區(qū)間及表達系統(tǒng)(Source)
Mouse IL-6, His Tag (IL6-M5245) is expressed from human 293 cells (HEK293). It contains AA Phe 25 - Thr 211 (Accession # P08505-1).
Predicted N-terminus: His
蛋白結構(Molecular Characterization)
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 23.6 kDa. The protein migrates as 25-35 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
白細胞介素6(IL-6)也稱為HGF、BSF2、HSF、IFNB2和IL-6,最初被鑒定為B細胞分化因子,是一種調節(jié)免疫反應、造血、急性期反應和炎癥反應的多功能細胞因子。它由T細胞、巨噬細胞、單核細胞、成纖維細胞、內皮細胞等分泌,以刺激對創(chuàng)傷的免疫反應,特別是燒傷或其他導致炎癥的組織損傷。白介素6已被證明與白介素-6受體和糖蛋白相互作用。IL-6與許多疾病過程有關,如糖尿病、動脈粥樣硬化、抑郁癥、阿爾茨海默病、系統(tǒng)性紅斑狼瘡、前列腺癌癥和類風濕性關節(jié)炎。晚期/轉移性癌癥患者血液中的IL-6水平較高。因此,人們有興趣開發(fā)抗IL-6藥物作為治療許多這些疾病的方法。
關鍵字: IL-6;IL-6蛋白;IL-6重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。