咖啡酸苯乙酯|T6429|TargetMol

價(jià)格	￥135	￥198	￥285
包裝	2mg	5mg	10mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

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產(chǎn)品詳情

中文名稱:咖啡酸苯乙酯	英文名稱:Caffeic Acid Phenethyl Ester
CAS:104594-70-9	品牌: TargetMol
產(chǎn)地: 美國	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.35%	產(chǎn)品類別: 抑制劑
貨號(hào): T6429

Product Introduction

Bioactivity

名稱	Caffeic Acid Phenethyl Ester
描述	Caffeic Acid Phenethyl Ester (Phenylethyl Caffeate) (CAPE) inhibits the activation of nuclear transcription factor NF-kappa B and may suppress p70S6K and Akt-driven signaling pathways, with antineoplastic, cytoprotective and immunomodulating activities. CAPE is the phenethyl alcohol ester of caffeic acid and a bioactive component of honeybee hive propolis. In addition, CAPE inhibits PDGF-induced proliferation of vascular smooth muscle cells through the activation of p38 mitogen-activated protein kinase (MAPK) and hypoxia-inducible factor (HIF)-1alpha and subsequent induction of heme oxygenase-1 (HO-1).
細(xì)胞實(shí)驗(yàn)	Human HT-1080 fibrosarcoma, human lung A549 adenocarcinoma and murine B16-BL6 melanoma cell lines are maintained in EMEM medium supplemented with 10% FCS, 0.1% sodium bicarbonate and 2 mM glutamine. Murine colon 26-L5 carcinoma cell line, on the other hand, is maintained in RPMI medium containing the same supplements as in EMEM. These are all highly metastatic cell lines except for A-549 carcinoma. Cellular viability is determined using the standard MTT assay. In brief, exponentially growing cells are harvested and 100 μl of cell suspension containing 2000 cells is plated in 96-well microtiter plates. After 24 h of incubation to allow for cell attachment, the cells are treated with varying concentrations of test samples in medium (100 μl) and incubated for 72 h at 37°C under 5% CO2. Three hours after the addition of MTT, the amount of formazan formed is measured spectrophotometrically at 550 nm with a Perkin Elmer HTS-7000 plate reader. The test samples are first dissolved in DMSO and then diluted with medium; the final concentration of DMSO is less than 0.25%. Normal also had the same extent of DMSO. 5-Fluorouracil (5-FU) and doxorubicin HCl are used as positive controls, and EC50 values are calculated from the mean values of data from 4 wells. (Only for Reference)
體外活性	Caffeic Acid Phenethyl Ester通過阻止NF-κB的p65亞單位進(jìn)入核內(nèi)，抑制了由棕櫚酸酯、神經(jīng)酰胺、骨脂酸和過氧化氫誘導(dǎo)的NF-κB激活。[1] 在多個(gè)腫瘤細(xì)胞系中，Caffeic Acid Phenethyl Ester展現(xiàn)出有希望的抗增殖活性，其EC50分別針對(duì)小鼠結(jié)腸26-L5細(xì)胞系、小鼠B16-BL6黑色素瘤細(xì)胞系、人類HT-1080纖維肉瘤細(xì)胞系和人類肺A549腺癌細(xì)胞系為1.76、3.16、13.7和44.0μM。[2] 作為一種強(qiáng)大的抗氧化劑，Caffeic Acid Phenethyl Ester在小腦顆粒細(xì)胞中發(fā)揮抗凋亡作用，其機(jī)制是通過阻斷ROS形成和抑制caspase活性。[3] 此外，Caffeic Acid Phenethyl Ester減輕了LPS刺激的HSCs的促炎表型，并通過抑制NF-κB信號(hào)傳導(dǎo)，減弱了LPS對(duì)HSCs誘導(dǎo)的對(duì)纖維生成細(xì)胞因子的敏感性。[4]
體內(nèi)活性	在體內(nèi)，Caffeic Acid Phenethyl Ester（10 mg/kg，i.p.）抑制了接種Lewis肺癌、結(jié)腸癌和黑色素瘤細(xì)胞的C57BL/6和BALB/c小鼠原發(fā)性腫瘤的生長和血管生成。[5] Caffeic Acid Phenethyl Ester（5, 10, 20 mg/kg）通過減少胸腺重量和/或胸腺及脾臟的細(xì)胞性，還顯示了體內(nèi)的免疫調(diào)節(jié)效應(yīng)。[6]
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 18.33 mg/mL (64.48 mM) Ethanol : 28.4 mg/mL (100 mM)
關(guān)鍵字	Apoptosis \| Nuclear factor-kappaB \| Inhibitor \| Nuclear factor-κB \| inhibit \| Caffeic Acid Phenethyl Ester \| NF-κB
相關(guān)產(chǎn)品	L-Glutamic acid \| Diallyl disulfide \| Metronidazole \| 5-Fluorouracil \| Dextran sulfate sodium salt (MW 4500-5500) \| Stavudine \| Tributyrin \| Myricetin \| L-Ascorbic acid \| Acetylcysteine \| Salicylic acid \| Sodium 4-phenylbutyrate
相關(guān)庫	抑制劑庫 \| 經(jīng)典已知活性庫 \| 已知活性化合物庫 \| 植物來源化合物庫 \| 抗癌天然產(chǎn)物庫 \| 中藥單體化合物庫 \| 天然產(chǎn)物庫 \| 抗病毒中藥單體化合物庫 \| 中藥抗炎分子庫 \| 抗感染天然產(chǎn)物庫

關(guān)鍵字：咖啡酸苯乙酯|||Phenylethyl Caffeate|||CAPE|TargetMol

公司簡介

上海陶術(shù)生物科技有限公司為美國Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國波士頓、德國慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過在中國市場五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊資本	566.2651萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊資本：566.2651萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場三路28號(hào)4樓

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