硫酸長(zhǎng)春新堿|T1270

價(jià)格	￥866
包裝	20mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-09-14

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產(chǎn)品詳情

中文名稱(chēng):硫酸長(zhǎng)春新堿	英文名稱(chēng):Vincristine sulfate
CAS:2068-78-2	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 99.87%	產(chǎn)品類(lèi)別: 抑制劑
貨號(hào): T1270

Product Introduction

Bioactivity

名稱(chēng)	Vincristine sulfate
描述	Vincristine sulfate is an alkaloidal natural product that binds to microtubule proteins and inhibits the formation of microtubules, thereby inhibiting mitosis in tumor cells. Vincristine sulfate is used as a microtubule destabilizing agent in research studies for the treatment of hematologic neoplasms such as leukemias and lymphomas, as well as in studies related to sarcomas in children.
細(xì)胞實(shí)驗(yàn)	SH-SY5Y cells at a logarithmic phase were seeded in 96-well plates (at 2x10^6/l) and incubated for 12 h until cells formed a monolayer. Wells were randomly chosen for treatment groups and a control group. For the treatment groups, cells were incubated with 200 μl of cell culture medium containing 0.001, 0.01, 0.1, 1 or 10 μM of VCR. In the control group, cells were grown in 200 μl cell culture medium only. Cells were incubated for another 24, 48 and 72 h and then 20 μl of 5 g/l MTT (0.1 mg/l final concentration) was added to each well. After 4 h of incubation, the cell culture supernatant was removed, 150 μl of DMSO was added to each well and the plate was shaken for 10 min. The absorbance of each well was detected at 490 nm (A value) on an ELISA plate reader. The growth inhibition rate of VCR-treated cells was calculated as: Growth inhibition rate % = [(average A value of control group - average A value of VCR-treated group)/average A value of control group] x 100%. This experiment was performed in triplicates [2].
動(dòng)物實(shí)驗(yàn)	Vincristine (1?mg/ml) was diluted in saline and administered i.v. to wild-type and Mdr1ab/Mrp1 TKO mice, aged 10–14 weeks, at dose levels ranging between 0.125 and 4?mg/kg. Animals were monitored daily and killed when they lost more than 20% of their initial body weight. The MTD was defined as one dose step below the dose where more than one animal in that group had to be killed. Necropsies were performed in wild-type and Mdr1ab/Mrp1 TKO mice receiving vincristine at or near the MTD and killed 2 days later [5].
體外活性	方法: 神經(jīng)母細(xì)胞瘤細(xì)胞 SH-SY5Y 用 Vincristine sulfate (0.001-10 μM) 處理 24-72 h，使用 MTT assay 檢測(cè)細(xì)胞活力。結(jié)果: Vincristine 對(duì) SH-SY5Y 細(xì)胞增殖的抑制作用具有劑量和時(shí)間依賴(lài)性。24、48 和 72 h的 IC50 分別為0.113 μM、0.078 μM 和 0.051 μM。[1] 方法: 人白血病細(xì)胞 MOLT-4 用 Vincristine sulfate (0.3-3 μM) 和 SAHA (500 nM) 處理 24-48 h，使用 Flow cytometry 檢測(cè)細(xì)胞周期。結(jié)果: 與 SAHA 相比，Vincristine 處理誘導(dǎo)細(xì)胞周期的 G2/M 期增加。Vincristine 加 SAHA 的組合在短期治療后 (24 h) 導(dǎo)致細(xì)胞幾乎完全停滯在 G2/M 期，隨后在長(zhǎng)期治療后 (48 h) 誘導(dǎo)細(xì)胞進(jìn)入 sub-G1 期。[2]
體內(nèi)活性	方法: 為檢測(cè)體內(nèi)抗腫瘤活性，將 Vincristine sulfate (0.025 mg/kg，靜脈注射，每周一次) 和 SAHA (200 mg/kg，口服給藥，每天一次) 給藥給攜帶 MOLT-4 異種移植物的 SCID 小鼠，持續(xù) 24 天。結(jié)果: 單獨(dú)用 Vincristine 或 SAHA 治療的小鼠的 TGD 沒(méi)有改善。然而，對(duì)數(shù)秩分析顯示，在 MOLT-4 異種移植物模型中，共處理表現(xiàn)出顯著的抗腫瘤活性。[2]
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 50 mg/mL (54.17 mM) Ethanol : < 1 mg/mL (insoluble or slightly soluble) H2O : 92.3 mg/mL (100 mM)
關(guān)鍵字	Inhibitor \| Microtubule/Tubulin \| NSC-67574 \| Vincristine \| Vincristine sulfate \| Vincristine Sulfate \| 22-Oxovincaleukoblastine \| Apoptosis \| NSC67574 \| Leurocristine Sulfate \| inhibit \| NSC 67574 \| 22-Oxovincaleukoblastine Sulfate
相關(guān)產(chǎn)品	Metronidazole \| 5-Fluorouracil \| Stavudine \| Tributyrin \| Dextran sulfate sodium salt (MW 4500-5500) \| Myricetin \| Sorafenib \| L-Ascorbic acid \| Acetylcysteine \| Sodium 4-phenylbutyrate
相關(guān)庫(kù)	抗癌上市藥物庫(kù) \| 經(jīng)典已知活性庫(kù) \| 抗癌活性化合物庫(kù) \| 植物來(lái)源化合物庫(kù) \| 已知活性化合物庫(kù) \| 抗衰老化合物庫(kù) \| FDA 上市藥物庫(kù) \| 抗癌臨床化合物庫(kù) \| 高通量篩選天然產(chǎn)物庫(kù) \| 抗癌藥物庫(kù)

關(guān)鍵字：硫酸長(zhǎng)春新堿|||Leurocristine|||22-Oxovincaleukoblastine sulfate|||Leurocristine sulfate|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專(zhuān)業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷(xiāo)售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿(mǎn)足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過(guò)在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過(guò)五百家學(xué)校和各類(lèi)企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

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公司成立：12年
注冊(cè)資本：566.2651萬(wàn)人民幣
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主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫(kù)，天然產(chǎn)物，活性分子化合物等
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