中文名稱:依匹斯汀鹽酸鹽 | 英文名稱:Epinastine hydrochloride |
CAS:108929-04-0 | 品牌: TargetMol |
產(chǎn)地: 美國 | 保存條件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
純度規(guī)格: 99.92% | 產(chǎn)品類別: 抑制劑 |
貨號: T6488 |
名稱 | Epinastine hydrochloride |
描述 | Epinastine hydrochloride (WAL-801CL HCl) is an antihistamine and mast cell stabilizer that is used in eye drops to treat allergic conjunctivitis. |
體外活性 | Epinastine shows a high affinity to H1-receptors in receptor binding studies in the guinea pig ileum. [1] Epinastine is able to displace specific [3H]NC-5Z binding at low concentrations in the locust nervous tissue. Epinastine binds to the honey bees neuronal octopamine receptor with Ki of 1.1 nM. Epinastine antagonises octopamine-induced cAMP formation in the insect brain. [2] Epinastine causes an inhibition of histamine release from rat peritoneal mast cells induced by both antigen-antibody reaction and compound 48/80. Epinastine is similarly effective in inhibiting compound 48/80-induced histamine release not only from isolated rat peritoneal mast cells but also from rat mesenterial pieces. Epinastine is effective in inhibiting not only Ca2+ uptake into lung mast cells in actively sensitized guinea pigs but also Ca2+ release from the intracellular Ca store of rat peritoneal mast cells exposed to both compound 48/80 and substance P. [3] Epinastine shows a dose- and time-dependent suppressive effect on IL-8, one of the chemokines for eosinophils, released from eosinophils isolated from atopic diseases. [4] |
體內(nèi)活性 | Epinastine inhibits histamine-induced reactions in the skin or the lung of rats, dogs and guinea pigs. [1] |
存儲條件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 50 mg/mL (174.97 mM) H2O : 52 mg/mL (182 mM) Ethanol : 53 mg/mL (185.5 mM) |
關(guān)鍵字 | antiallergic | inhibit | Epinastine Hydrochloride | Epinastine | WAL801 | WAL 801 | insect | Histamine Receptor | mast | Inhibitor | WAL-801 | Antihistamine | cell | Epinastine hydrochloride | vertebrate | neuronal |
相關(guān)產(chǎn)品 | Famotidine | Meclizine dihydrochloride | Lidocaine | Cinchonidine | Sodium butanoate | Alginic acid | Alverine citrate | Dapoxetine hydrochloride | Trazodone hydrochloride | Mianserin hydrochloride | Fluoxetine hydrochloride | CLOZAPINE N-OXIDE |
相關(guān)庫 | 抑制劑庫 | 經(jīng)典已知活性庫 | 已知活性化合物庫 | FDA 上市藥物庫 | GPCR靶點分子庫 | 膜蛋白靶向化合物庫 | 神經(jīng)退行性疾病化合物庫 | 藥物功能重定位化合物庫 | 疼痛相關(guān)化合物庫 | 抗癌臨床化合物庫 |
成立日期 | 2013-04-18 (12年) | 注冊資本 | 566.2651萬人民幣 |
員工人數(shù) | 100-500人 | 年營業(yè)額 | ¥ 1億以上 |
主營行業(yè) | 化學(xué)試劑,生物活性小分子 | 經(jīng)營模式 | 貿(mào)易,試劑,定制,服務(wù) |
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