咖啡酸乙酯|T5681

價(jià)格	￥289	￥539	￥877
包裝	10mg	25mg	50mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-09-14

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產(chǎn)品詳情

中文名稱(chēng):咖啡酸乙酯	英文名稱(chēng):ETHYL CAFFEATE
CAS:102-37-4	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 97.79%	產(chǎn)品類(lèi)別: 抑制劑
貨號(hào): T5681

Product Introduction

Bioactivity

名稱(chēng)	ETHYL CAFFEATE
描述	Ethyl Caffeate (ETHYL 3,4-DIHYDROXYCINNAMATE) suppressed the differentiation of naive CD4+ T cells into Th1 in vitro. Furthermore, Ethyl Caffeate intensely blocked the transcriptional expression in interferon-γ-related signaling, including IFN-γ, T-bet, STAT1, and STAT4.
細(xì)胞實(shí)驗(yàn)	Collagen was dissolved in 0.1 M acetic acid at 4°C overnight.?Male DBA/1 mice were immunized at the tail base with 125?μg of collagen emulsified in complete Freund's adjuvant (CFA) containing Mycobacterium tuberculosis strain H37Rv.?Each mouse was then boosted with the same amount of collagen plus CFA 21 days later (taken as day 0). Starting from day 9 for 10 consecutive days, the mice were administered daily with ECF (50?mg/kg) or methotrexate (2?mg/kg)
激酶實(shí)驗(yàn)	The proliferation of splenocytes or T cells in response to ConA, LPS, and anti-CD3/28 was measured by CCK-8 Kit.?Briefly, BALB/c splenocyte suspension (5?×?105 cells/well) was cultured with ConA (5?μg/ml), LPS (10?μg/ml), and anti-CD3 (5?μg/ml;?145-2C11) in the presence of ECF at indicated concentrations.?The cultures were incubated for 48?h, 20?μl of CCK-8 was then added to each well before the end of culture, and OD value was read at 450?nm.?The MTT method was used to measure the cytotoxicity of the sample.?Splenocytes (5?×?105 cells/well) were cultured in triplicates in the absence or presence of ECF in a 96-well flat-bottomed plate (Costar) for 48?h.?MTT (5?mg/ml) was pulsed for 4?h prior to the end of the culture.?Upon removal of MTT/medium, 150?μl of DMSO was added to each well, and the plate was agitated on an oscillator for 5?min to dissolve the precipitate.?The assay plate was read at 570?nm using a microplate reader.
體外活性	體內(nèi)實(shí)驗(yàn)中，ETHYL CAFFEATE(ECF)處理顯著減輕了膠原誘導(dǎo)性關(guān)節(jié)炎(CIA)的嚴(yán)重程度，抑制了IFN-γ和IL-6的分泌，并降低了CD11b+Gr-1+脾臟嗜中性白細(xì)胞的比例。同時(shí)，ECF處理在不明顯影響Th17細(xì)胞和調(diào)節(jié)性T細(xì)胞發(fā)展的情況下，顯著抑制了CD4+T細(xì)胞中IFN-γ的表達(dá)。
體內(nèi)活性	Shikui X、Aixue Z、Zengjun G 等人研究顯示，Ethyl Caffeate 通過(guò)抑制Th1免疫應(yīng)答，有效緩解膠原誘導(dǎo)的關(guān)節(jié)炎[J]。
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : 41 mg/mL (196.91 mM)
關(guān)鍵字	Nuclear factor-kappaB \| Inhibitor \| NF-κB \| Cyclooxygenase \| PGE synthase \| Prostaglandin E synthase \| COX \| ETHYL CAFFEATE \| inhibit \| Nitric oxide synthases \| NOS \| Nuclear factor-κB \| NO Synthase
相關(guān)產(chǎn)品	Diallyl disulfide \| Glucosamine \| Acetaminophen
相關(guān)庫(kù)	神經(jīng)保護(hù)化合物庫(kù) \| 抑制劑庫(kù) \| 經(jīng)典已知活性庫(kù) \| 植物來(lái)源化合物庫(kù) \| 古代經(jīng)典名方目錄分子庫(kù) \| 苗藥化合物庫(kù) \| 中藥單體化合物庫(kù) \| 天然產(chǎn)物庫(kù) \| 疼痛相關(guān)化合物庫(kù) \| 高通量篩選天然產(chǎn)物庫(kù)

關(guān)鍵字：咖啡酸乙酯|||ETHYL 3,4-DIHYDROXYCINNAMATE|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專(zhuān)業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷(xiāo)售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿(mǎn)足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過(guò)在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過(guò)五百家學(xué)校和各類(lèi)企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬(wàn)人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊(cè)資本：566.2651萬(wàn)人民幣
企業(yè)類(lèi)型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫(kù)，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

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