Human CEACAM-6 / CD66c Protein, His Tag
分子別名(Synonym)
CEACAM6,CD66c,CEAL,NCA
表達區(qū)間及表達系統(tǒng)(Source)
Human CEACAM-6, His Tag (CE6-H5223) is expressed from human 293 cells (HEK293). It contains AA Lys 35 - Gly 320 (Accession # NP_002474.3).
Predicted N-terminus: Lys 35
蛋白結構(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 32.0 kDa. The protein migrates as 45-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
癌胚抗原相關細胞粘附分子6(非特異性交叉反應抗原)(CEACAM6)也稱為CD66c(分化簇66c)、CEAL、NCA,是免疫球蛋白超家族中的七個人類CEACAM家族成員之一。在人類中,CEACAMs包括I型跨膜蛋白(CEACAM1、CEACAM3和CEACAM4)和GPI連接分子(CEACAM5至CEACAM8)。沒有人類CEACAM2。CEACAM 6包含一個N端V型Ig樣結構域(N結構域),后面是兩個C2型Ig樣域。它顯示出相當大的糖基化,包括(唾液酸基)LewisX,它介導與E-選擇素、半乳凝素和一些細菌膜的結合。CEACAM-6由粒細胞及其祖細胞表達。它也由各種器官的上皮細胞表達,在胰腺癌和結腸癌以及增生性息肉中上調。在CEACAM6過表達的情況下,腫瘤細胞對粘附相關凋亡具有抗性。
關鍵字: CEACAM-6;CEACAM6蛋白;CD66c蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。