Human uPAR / PLAUR Protein, His Tag (MALS verified)
分子別名（Synonym）
uPAR,PLAUR,CD87,MO3
表達區(qū)間及表達系統（Source）
Human uPAR, His Tag (UPR-H5226) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Arg 303 (Accession # AAH02788).
Predicted N-terminus: Leu 23
蛋白結構（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 32.3 kDa. The protein migrates as 40-55 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內毒素（Endotoxin）
Less than 1.0 EU per μg by the LAL method.
純度（Purity）
>92% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
尿激酶纖溶酶原激活物表面受體（U-PAR）也稱為PLAUR、單核細胞激活抗原Mo3、CD抗原CD87。PLAUR包含三個UPAR/Ly6結構域。U-PAR在大腦外側區(qū)的神經元中表達（在蛋白質水平上），也在大腦中表達。PLAUR/CD87與MRC2、SRPX2和SORL1相互作用。PLAUR/UPAR作為尿激酶型纖溶酶原激活物的受體，在定位和促進纖溶酶形成方面發(fā)揮作用。U-PAR介導U-PA的蛋白水解非依賴性信號轉導激活效應。
關鍵字： uPAR;uPAR蛋白;uPAR重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下擁有品牌ACROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。