Human CD4 / LEU3 Protein, His Tag (MALS verified)
分子別名（Synonym）
CD4,CD4mut,LEU3
表達區(qū)間及表達系統(tǒng)（Source）
Human CD4, His Tag (LE3-H5228) is expressed from human 293 cells (HEK293). It contains AA Lys 26 - Trp 390 (Accession # AAH25782).
Predicted N-terminus: Lys 26
蛋白結(jié)構(gòu)（Molecular Characterization）
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 41.5 kDa. The protein migrates as 47-54 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素（Endotoxin）
Less than 0.1 EU per μg by the LAL method.
純度（Purity）
>90% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
T細胞表面糖蛋白CD4也稱為T細胞表面抗原T4/Leu-3。CD4包含三個Ig樣C2型（免疫球蛋白樣）結(jié)構(gòu)域和一個Ig樣V型（免疫蛋白樣）功能域。CD4是MHC II類抗原/T細胞受體相互作用的輔助蛋白。CD4誘導(dǎo)脂筏聚集。CD4是HIV-1用于進入宿主T細胞的主要受體。HIV感染導(dǎo)致具有CD4受體的T細胞數(shù)量逐漸減少。因此，醫(yī)療專業(yè)人員參考CD4計數(shù)來決定何時開始治療HIV感染患者。
關(guān)鍵字： CD4;CD4蛋白;CD4重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。