Human IL-17F Protein, His Tag (MALS verified)
分子別名(Synonym)
IL-17F,Interleukin-17F,Cytokine ML-1
表達區(qū)間及表達系統(tǒng)(Source)
Human IL-17F, His Tag (ILF-H5244) is expressed from human 293 cells (HEK293). It contains AA Arg 31 - Gln 163 (Accession # Q96PD4-1).
Predicted N-terminus: His
蛋白結構(Molecular Characterization)
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 16.8 kDa. The protein migrates as 22-25 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
白細胞介素-17F(IL17F)也稱為白細胞介蛋白-24(IL24)、細胞因子ML-1,是一種分泌的二硫鍵連接的同二聚體,屬于IL-17家族。在人類和小鼠中,IL-17家族至少有六個成員:IL-17A、IL-17B、IL-17C、IL-17D、IL-17E(也稱為IL-25)和IL-17F(也稱為IL-24)。IL-17代表了一個結構相關的細胞因子家族,它們共享一個高度保守的C末端區(qū)域,但在N末端區(qū)域和不同的生物學作用上彼此不同。IL-17F/IL-24在活化的CD4+T細胞和活化的單核細胞中表達,但在靜息狀態(tài)下不表達。IL17F/白細胞介素-24刺激其他細胞因子如IL-6、IL-8和粒細胞集落刺激因子的產生,并可以調節(jié)軟骨基質的周轉。IL17F/IL-24刺激PBMC和T細胞增殖并抑制血管生成。IL17F缺陷是家族性6型念珠菌?。?/span>CANDF6)的原因。
關鍵字: IL-17F;IL-17F蛋白;IL-17F重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產業(yè)領域提供關鍵生物試劑產品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產基地。目前累計服務客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。