Human IL-23R Protein, Fc Tag (MALS verified)

分子別名（Synonym）

IL-23R,IL-23 Receptor

表達(dá)區(qū)間及表達(dá)系統(tǒng)（Source）

Human IL-23R, Fc Tag (ILR-H5254) is expressed from human 293 cells (HEK293). It contains AA Gly 24 - Gly 355 (Accession # Q5VWK5-1).

Predicted N-terminus: Gly 24

蛋白結(jié)構(gòu)（Molecular Characterization）

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 64.5 kDa. The protein migrates as 90-100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>95% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

背景（Background）

白介素23受體（IL-23R）是一種I型細(xì)胞因子受體，IL-23R與受體分子IL12RB1/IL12Rbeta1配對(duì)，兩者都是IL23A信號(hào)傳導(dǎo)所必需的。此外，IL-23R與Janus激酶2（JAK2）組成性結(jié)合，并以配體依賴的方式與轉(zhuǎn)錄激活劑STAT3結(jié)合。此外，IL-23R可能通過激活Jak-Stat信號(hào)級(jí)聯(lián)來介導(dǎo)T細(xì)胞、NK細(xì)胞和可能的某些巨噬細(xì)胞/髓細(xì)胞刺激。至于IL-23，它可能與自身免疫性炎癥性疾病有關(guān)，并對(duì)腫瘤發(fā)生具有重要意義。