Human Mesothelin / MSLN (296-580) Protein, His Tag, premium grade
分子別名(Synonym)
MSLN,Mesothelin,MPF
表達區(qū)間及表達系統(tǒng)(Source)
Human Mesothelin (296-580), His Tag, premium grade (MSN-H522a) is expressed from human 293 cells (HEK293). It contains AA Glu 296 - Gly 580 (Accession # AAH09272).
Predicted N-terminus: Glu 296
它是在我們嚴格的質(zhì)量控制體系下生產(chǎn)的,該體系包括一套全面的檢測,包括無菌和內(nèi)毒素檢測。在臨床前早期階段,仔細驗證產(chǎn)品性能,并測試其與細胞培養(yǎng)用途或任何其他應(yīng)用的兼容性。當(dāng)準(zhǔn)備好過渡到后期臨床階段時,我們還提供定制的GMP蛋白質(zhì)服務(wù),以滿足您的需求。我們將與您合作,根據(jù)您的要求定制和開發(fā)GMP級產(chǎn)品,該產(chǎn)品也符合細胞治療的細胞制造中使用的原材料和輔助材料的要求。
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries a polyhistidine tag at the C-terminus.
The protein has a calculated MW of 33.0 kDa. The protein migrates as 38-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素(Endotoxin)
Less than 0.01 EU per μg by the LAL method.
無菌(Sterility)
Negative
支原體(Mycoplasma)
Negative.
純度(Purity)
>90% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
間皮素(MSLN)也被稱為CAK1抗原,前巨核細胞增強因子,屬于間皮素家族。間皮素/MSLN可以通過弗林樣轉(zhuǎn)化酶蛋白水解切割成以下兩條鏈:巨核細胞增強因子(MPF)和切割形式的間皮素。MPF和間皮素的裂解形式都是N-糖基化的。間皮素/MSLN可以與MUC16相互作用。膜錨定形式的MSLN可能在細胞粘附中發(fā)揮作用。MPF在體外增強巨核細胞集落的形成。
關(guān)鍵字: Mesothelin;Mesothelin蛋白;Mesothelin重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國、美國、瑞士等12個城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關(guān)系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。