Human EGF Protein, His Tag, premium grade
分子別名（Synonym）
EGF,URG,HOMG4
表達區(qū)間及表達系統(tǒng)（Source）
Human EGF Protein, His Tag, premium grade (EGF-H52H3) is expressed from human 293 cells (HEK293). It contains AA Asn 971 - Arg 1023 (Accession # P01133-1).
It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage. When ready to transition into later clinical phases, we also offer a custom GMP protein service that tailors to your needs. We will work with you to customize and develop a GMP-grade product in accordance with your requests that also meets the requirements for raw and ancillary materials use in cell manufacturing of cell-based therapies.
蛋白結構（Molecular Characterization）
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 8.3 kDa. The protein migrates as 10-11 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.
內(nèi)毒素（Endotoxin）
Less than 0.1 EU per μg by the LAL method.
無菌（Sterility）
Negative
支原體（Mycoplasma）
Negative.
純度（Purity）
>95% as determined by SDS-PAGE.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
背景（Background）
人表皮生長因子（EGF）也稱為HOMG4和URG，是一種生長因子，通過與其受體EGFR結合在調(diào)節(jié)細胞生長，增殖和分化中起重要作用。表皮生長因子可以在人血小板，巨噬細胞，尿液，唾液，牛奶和血漿中發(fā)現(xiàn)。EGF是EGF蛋白家族的創(chuàng)始成員。所有家族成員都包含一個或多個保守氨基酸序列的重復序列。唾液EGF的生物學效應包括口腔和胃食管潰瘍的愈合，胃酸分泌的抑制，D合成的刺激以及粘膜保護免受腔內(nèi)有害因素（如胃酸，膽汁酸，胃蛋白酶和胰蛋白酶）以及物理，化學和細菌劑。由于EGF會增加患癌癥的風險，因此抑制它會降低患癌癥的風險。
關鍵字： EGF;EGF蛋白;EGF重組蛋白;ACRO;百普賽斯;
百普賽斯集團ACROBiosystems Group（股票代碼：301080）是成立于2010年的跨國生物科技公司，是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領域提供關鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團業(yè)務遍布全球，橫跨亞洲、北美洲、歐洲，在中國、美國、瑞士等12個城市設有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計服務客戶超6000家，與全球Top 20醫(yī)藥企業(yè)均建立了長期、穩(wěn)定的合作伙伴關系。集團旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學等。