IL-1R1產(chǎn)品信息
別稱:IL-1R1
物種:Human
屬性:Protein
標(biāo)記:Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
IL-1R1分子背景
IL1R1也稱為白細(xì)胞介素-1受體1型,是IL1A、IL1B和IL1RN的受體。與白細(xì)胞介蛋白-1結(jié)合后,與輔助受體IL1RAP結(jié)合形成高親和力白細(xì)胞介素-1受體復(fù)合物,介導(dǎo)白細(xì)胞介導(dǎo)NF-kappa-B、MAPK和其他途徑的白細(xì)胞介介素-1依賴性激活。信號(hào)傳導(dǎo)涉及通過(guò)受體/共受體亞基的相應(yīng)TIR結(jié)構(gòu)域招募銜接分子,如TOLLIP、MYD88和IRAK1或IRAK2。以相當(dāng)?shù)挠H和力結(jié)合配體,與拮抗劑IL1RN結(jié)合可防止與IL1RAP結(jié)合形成信號(hào)復(fù)合物。參與IL1B介導(dǎo)的T輔助1(Th1)細(xì)胞產(chǎn)生IFNG的共刺激。
關(guān)鍵字: IL-1R1;IL-1R1蛋白;IL-1R1重組蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國(guó)生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。