Product Name：Cortistatin 17, human
CAS No.：189450-19-9
Synonyms：人源皮質(zhì)抑素-17
Catalog No.：182P13
Brand：HongTide（上海鴻肽生物）
Description：Cortistatin 17, human是由17個(gè)氨基酸組成的環(huán)狀多肽，顯示出與生長(zhǎng)抑素的結(jié)構(gòu)相似性。Cortistatin 17, human以與大鼠皮質(zhì)抑素相似的方式與所有生長(zhǎng)抑素受體亞型 (SSTR) 結(jié)合。 其對(duì)表達(dá) SSTR2-5 的中國(guó)倉(cāng)鼠卵巢細(xì)胞中毛喉素刺激的 cAMP 產(chǎn)生的抑制作用是劑量依賴(lài)性的，但比生長(zhǎng)抑素 14 的效果略低。與大鼠皮質(zhì)抑素一樣，Cortistatin 17, human對(duì)大鼠的睡眠和覺(jué)醒模式有影響。Cortistatin 17, human以劑量依賴(lài)的方式減少輕度慢波睡眠（SWS1）并增加深度慢波睡眠（SWS2）。Cortistatin 17, human的施用導(dǎo)致皮質(zhì)和海馬腦電圖暫時(shí)變平。
Cortistatin 17, human, is a cyclic peptide composed of 17 amino acids, exhibiting structural similarity to somatostatin. Cortistatin 17 binds to all somatostatin receptor subtypes (SSTR) in a similar manner to rat corticostatin. Its inhibitory effect on cAMP production stimulated by hirsutin in Chinese hamster ovarian cells expressing SSTR2-5 is dose-dependent, but slightly lower than the effect of somatostatin 14. Like rat corticostatin, Cortistatin 17, human has an impact on sleep and wakefulness patterns in rats. Cortistatin 17, human reduces mild slow wave sleep (SWS1) and increases deep slow wave sleep (SWS2) in a dose-dependent manner. The use of Cortistatin 17 and human resulted in temporary flattening of cortical and hippocampal electroencephalograms.
Purity (HPLC) ≥98.0%
Single impurity≤2%
Peptide content≥75.0%
Amino Acid Composition≤±15%
Bacterial Endotoxins≤50EU/mg
Solubility：H2O/DMSO
Vacuum-packed with aluminum foil bag or transparent bag.Various weights can be packed according to your requirements.
Storage:Cool dry place( Store at -20°C, away from the light)
Remark:For Research Use Only. Not for human use.
Sequence(1-letter code) | DRMPCRNFFWKTFSSCK(Disulfide bridge：Cys5-Cys16) |
Sequence(3-letter code) | H-Asp-Arg-Met-Pro-Cys-Arg-Asn-Phe-Phe-Trp-Lys-Thr-Phe-Ser-Ser-Cys-Lys-OH(Disulfide bridge Cys5-Cys16) |
Peptide Structure | 
|
Molecular Formula | C96H139N27O24S3 |
Molecular Weight | 2151.54 |
訂購(gòu)聯(lián)系方式：
上海鴻肽生物科技有限公司
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關(guān)鍵字： 189450-19-9;人源皮質(zhì)抑素-17;Cortistatin 17, huma;多肽;多肽合成;
上海鴻肽生物科技有限公司（簡(jiǎn)稱(chēng)：鴻肽生物）是一家以多肽以及多肽上下游產(chǎn)品研發(fā)、生產(chǎn)、銷(xiāo)售以及技術(shù)轉(zhuǎn)讓為主要業(yè) 務(wù)科技公司。公司現(xiàn)有產(chǎn)品涵蓋：定制多肽、目錄多肽、氨基酸衍生物、小分子化合物；公司自成立以來(lái)，秉持“用質(zhì)量作船， 以服務(wù)為帆，為科研服務(wù)”的企業(yè)理念，為國(guó)內(nèi)外眾多科研工作者提供了優(yōu)質(zhì)的服務(wù)及產(chǎn)品。