FGF R3 (IIIb)產(chǎn)品信息
英文名稱:Fibroblast growth factor receptor 3
中文名稱:成纖維細(xì)胞生長(zhǎng)因子受體-3
靶點(diǎn)別稱:FGF R3 (IIIb),FGF R3B,CD333
物種:Human
屬性:Protein
標(biāo)記:Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
>90% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution.
FGF R3 (IIIb)分子背景
成纖維細(xì)胞生長(zhǎng)因子受體(FGFR)是一種跨膜激酶蛋白,由于分子改變的頻率和與多種其他信號(hào)通路的廣泛接口,在癌癥生物學(xué)中具有越來(lái)越重要的意義。FGFR3基因位于人類染色體位點(diǎn)4p16.3,也編碼兩種亞型:FGF R3(IIIb)FGF R3(III c)。在大量腫瘤中也發(fā)現(xiàn)FGFR3蛋白表達(dá)上調(diào)。此外,FGFR3已被發(fā)現(xiàn)通過(guò)激活PLCγ信號(hào)級(jí)聯(lián)引發(fā)對(duì)三苯氧胺的耐藥性。
關(guān)鍵字: FGFR3;FGFR3蛋白;FGF R3 (IIIb)蛋白;ACRO;百普賽斯;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國(guó)生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。