FGF9產(chǎn)品信息

別稱：FGF9,GAF,HBFG-9

物種：Human

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>92% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 100 mM Glycine, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

FGF9分子背景

成纖維細(xì)胞生長因子9也稱為FGF9、GAF、HBFG-9、SYNS3，是成纖維細(xì)胞增長因子（FGF）家族的成員。FGF家族成員具有廣泛的促有絲分裂和細(xì)胞存活活性，參與多種生物過程，包括胚胎發(fā)育、細(xì)胞生長、形態(tài)發(fā)生、組織修復(fù)、腫瘤生長和侵襲。FGF9也是少突膠質(zhì)細(xì)胞2型星形膠質(zhì)細(xì)胞祖細(xì)胞、平滑肌細(xì)胞、嗜鉻細(xì)胞瘤PC12細(xì)胞和BALB/3T3成纖維細(xì)胞的有絲分裂原。然而，與酸性和堿性FGF不同，FGF9對(duì)人臍靜脈內(nèi)皮細(xì)胞沒有影響，并且已經(jīng)證明FGF9優(yōu)先與FGFR3的IIIc形式結(jié)合。盡管在FGF9中沒有發(fā)現(xiàn)典型的信號(hào)序列，但它在合成后不是以傳統(tǒng)方式有效分泌的。在神經(jīng)系統(tǒng)中，FGF9主要由神經(jīng)元產(chǎn)生，可能在中樞神經(jīng)系統(tǒng)發(fā)育中發(fā)揮重要作用。FGF9已被證明與成纖維細(xì)胞生長因子受體3相互作用。