IL-1 RII產(chǎn)品信息

別稱(chēng)：CD121b,IL1RB,IL1R2,CDw121b

物種：Human

屬性：Protein

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>98% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

-20°C to -70°C for 12 months in lyophilized state;

-70°C for 3 months under sterile conditions after reconstitution.

IL-1 RII分子背景

白細(xì)胞介素-1受體2型（IL1R2）也被稱(chēng)為CD121抗原樣家族成員B（CDw121b），IL-1 II型受體，IL-1受體II型，屬于白細(xì)胞介蛋白-1受體家族。已經(jīng)鑒定出能夠特異性結(jié)合IL1的兩種不同類(lèi)型的IL1受體，分別命名為IL1RI（IL1RA）和IL1RII（IL1RB）。IL1R2是IL1A、IL1B和IL1RN的非信號(hào)受體，可降低IL1B活性。通過(guò)與IL1B競(jìng)爭(zhēng)性結(jié)合并阻止其與IL1R1結(jié)合，充當(dāng)誘餌受體。IL1R2在與IL1B結(jié)合后通過(guò)與IL1RAP的非信號(hào)關(guān)聯(lián)調(diào)節(jié)細(xì)胞反應(yīng)。IL1R2（膜型和分泌型）優(yōu)先結(jié)合IL1B，弱結(jié)合IL1A和IL1RN。分泌型IL1R2以高親和力招募分泌型IL1RAP；這種復(fù)合物的形成可能是分泌/可溶性受體中和IL1B的主要機(jī)制。