Interleukine 10 (IL-10) is a cytokine produced primarily by monocytes and to a lesser extent bylymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules onmacrophages. It also enhances B cell survival, proliferation, and antibody production. Thiscytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signalingpathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
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