中文名：PLX5622
英文名：PLX5622
英文別名：3-?Pyridinemethanamine, 5-?fluoro-?N-?[6-?fluoro-?5-?[(5-?methyl-?1H-?pyrrolo[2,?3-?b]?pyridin-?3-?yl)?methyl]?-?2-?pyridinyl]?-?2-?methoxy-
純度：10mM in DMSO
貨號：P409126
包裝：1ml
Cas號：1303420-67-8
存儲溫度：-80℃儲存
產(chǎn)品介紹：
Information
PLX5622 PLX5622 is a highly selective CSF-1R inhibitor (IC50 < 10 nmol/L), showing?>?20-fold selectivity over KIT and FLT3.
In?vitro
In?vivo
In vivo PLX5622 demonstrates desirable PK properties in mice, rats, dogs, and monkeys, with a brain penetrance of ~20%. PLX5622 has low systemic clearance, moderate volume of distribution, and favorable oral bioavailability (F > 30%) in all four species. PLX5622 is a useful compound for investigating microglial dynamics. It allows for the sustained and specific elimination of microglia, preceding and during pathology development of Alzheimer’s disease (AD). Long-term PLX5622-mediated microglial depletion is highly robust, sustainable, and specific to the microglial compartment.
Cell?Data
cell?lines：Ba/F3 cells expressing JAK2V617F (Ba/F3-EpoR-V617F) and MPLW515L (Ba/F3-W515L) mutants.
Concentrations：
Incubation?Time：
Powder?Purity:≥98%
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關(guān)鍵字： 3-?Pyridinemethanamine, 5-?fluoro-?N-?[6-?fluoro-?5-?[(5-?methyl-?1H-?pyrrolo[2,?3-?b]?pyridin-?3-?yl)?methyl]?-?2-?pyridinyl]?-?2-?methoxy-
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