中文名：Ro 48-8071,2,3-氧化鯊烯環(huán)化酶（OSC）抑制劑
英文名：Ro 48-8071
中文別名：(4-溴苯基)-[2-氟-4-[6-[甲基(丙-2-烯基)氨基]己氧基]苯基]甲酮
英文別名：Ro 48-8071 fumarate|189197-69-1|Ro 48-8071 (fumarate)|Ro-48-8071 fumarate|Ro48-8071fumarate|(4-((6-(Allyl(methyl)amino)hexyl)oxy)-2-fluorophenyl)(4-bromophenyl)methanone fumarate|7YBF6VZ4ML|CHEMBL324162|(4-bromophenyl)-[2-fluoro-4-[6-[methyl(prop-2-enyl)a
純度：≥98%
貨號：R276229
包裝：10mg、50mg、100mg
Cas號：189197-69-1
存儲溫度：避光,-20°C儲存
產(chǎn)品介紹：
儲存在室溫下。該產(chǎn)品最多可存儲12個月。
?An? ?benzofuranylallylamine compound that acts as a potent, active site targeting, competitive and reversible inhibitor of 2,3-oxidosqualene:lanosterol cyclase activity (OSC; IC50 ~ 6.5 nM against mammalian) and reduces cholesterol synthesis (IC50 ~ 1.5 nM in HepG2 cells) with minimal buildup of both dioxidosqualene and monooxidosqualene. Downregulates 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA and synthesis, and exerts less adverse effects in animal models than Statins. Shown to preferentially enhance the DNA-binding affinity of mutant p53 and arrest the growth of human breast cancer cells (IC50 ~ 10 μM).
An? ?benzofuranylallylamine compound that acts as a potent, active site targeting, competitive and reversible inhibitor of 2,3-oxidosqualene:lanosterol cyclase activity (OSC; IC50 ~6.5 nM against mammalian) and reduces cholesterol synthesis (IC50 ~1.5 nM in HepG2 cells) with minimal buildup of both dioxidosqualene and monooxidosqualene. Downregulates 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase mRNA and synthesis, and exerts less adverse effects in animal models than Statins. Shown to preferentially enhance the DNA-binding affinity of mutant p53 and arrest the growth of human breast cancer cells (IC50 ~10 μM).
Ro 48-8071 fumarate 是氧化鯊烯環(huán)化酶 (Oxidosqualene cyclase) 抑制劑，IC50 約為 6.5 nM。
查看阿拉丁官網(wǎng)此產(chǎn)品相關(guān)對應(yīng)頁面：https://www.aladdin-e.com/zh_cn/R276229.html
關(guān)鍵字： (4-溴苯基)-[2-氟-4-[6-[甲基(丙-2-烯基)氨基]己氧基]苯基]甲酮;Ro 48-8071 fumarate;189197-69-1;Ro 48-8071 (fumarate)
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