BMP-2產(chǎn)品信息
英文名稱(chēng):Bone morphogenetic protein 2
中文名稱(chēng):骨形態(tài)生成蛋白2
靶點(diǎn)別稱(chēng):BMP2,BMP2A
物種:Human
標(biāo)簽:Tag Free
屬性:Protein
標(biāo)記:Unconjugated
表達(dá)區(qū)間及表達(dá)系統(tǒng)(Source)
Human BMP-2 Protein, premium grade (BM2-H4117) is expressed from E. coli cells. It contains AA Ala 284 - Arg 396 (Accession # NP_001191 ).
Predicted N-terminus: Met
It is produced under our rigorous quality control system that incorporates a comprehensive set of tests including sterility and endotoxin tests. Product performance is carefully validated and tested for compatibility for cell culture use or any other applications in the early preclinical stage. When ready to transition into later clinical phases, we also offer a custom GMP protein service that tailors to your needs. We will work with you to customize and develop a GMP-grade product in accordance with your requests that also meets the requirements for raw and ancillary materials use in cell manufacturing of cell-based therapies.
蛋白結(jié)構(gòu)(Molecular Characterization)
This protein carries no "tag"
The protein has a calculated MW of 12.8 kDa. The protein migrates as 14 kDa under reducing (R) condition, and 28 kDa under non-reducing (NR) condition (SDS-PAGE).
內(nèi)毒素(Endotoxin)
Less than 0.2 EU per μg by the LAL method.
無(wú)菌(Sterility)
The sterility testing was performed by membrane filtration method.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in 100 mM Acetic Acid, pH2.8 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
BMP-2分子背景
人骨形態(tài)發(fā)生蛋白2(BMP2)也稱(chēng)為人BMP-2、BMP-2、BMP 2、BMP2、h-BMP-2、rh-BMP-2、重組人BMP-2,重組BMP-2,BMP,是屬于結(jié)構(gòu)相關(guān)信號(hào)蛋白TGF-b超家族的BMP亞組的成員。BMP-2是一種強(qiáng)效的骨誘導(dǎo)細(xì)胞因子,能夠與膠原和合成羥基磷灰石等骨傳導(dǎo)載體結(jié)合誘導(dǎo)骨和軟骨形成。除了其成骨活性外,BMP-2在心臟形態(tài)發(fā)生中起著重要作用,并在肺、脾、腦、肝、前列腺、卵巢和小腸等多種組織中表達(dá)。正如其名稱(chēng)所暗示的那樣,BMPs在眼睛、心臟、腎臟、皮膚和其他組織的產(chǎn)前發(fā)育和產(chǎn)后生長(zhǎng)中促進(jìn)和調(diào)節(jié)骨骼發(fā)育、生長(zhǎng)、重塑和修復(fù)。BMP2已被證明能有效誘導(dǎo)多種細(xì)胞類(lèi)型的成骨細(xì)胞分化,并作為一種新功能誘導(dǎo)人骨髓瘤細(xì)胞系凋亡。
關(guān)鍵字: BMP-2;BMP-2蛋白;BMP2;BMP2蛋白;骨形態(tài)生成蛋白2;
百普賽斯集團(tuán)ACROBiosystems Group(股票代碼:301080)是成立于2010年的跨國(guó)生物科技公司,是為全球生物醫(yī)藥、健康產(chǎn)業(yè)領(lǐng)域提供關(guān)鍵生物試劑產(chǎn)品及解決方案的行業(yè)平臺(tái)型基石企業(yè)。2021年在創(chuàng)業(yè)板上市。百普賽斯集團(tuán)業(yè)務(wù)遍布全球,橫跨亞洲、北美洲、歐洲,在中國(guó)、美國(guó)、瑞士等12個(gè)城市設(shè)有辦公室、研發(fā)中心及生產(chǎn)基地。目前累計(jì)服務(wù)客戶(hù)超6000家,與全球Top 20醫(yī)藥企業(yè)均建立了長(zhǎng)期、穩(wěn)定的合作伙伴關(guān)系。集團(tuán)旗下?lián)碛衅放艫CROBiosystems百普賽斯、bioSeedin柏思薈、Condense Capital墾拓資本和ACRODiagnostics百斯醫(yī)學(xué)等。