Complement C3產(chǎn)品信息
英文名稱:Complement C3
中文名稱:補體C3
靶點別稱:Complement C3,CPAMD1
物種:Human / Mouse / Cynomolgus
屬性:Protein
標(biāo)記:Biotin-labeled / Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
Complement C3分子背景
補體C3是血清中的主要補體成分。它主要由巨噬細(xì)胞和肝臟合成。C3在補體系統(tǒng)的激活中起著核心作用。C3轉(zhuǎn)化酶對其的處理是經(jīng)典和替代補體途徑的核心反應(yīng)。它被切割成兩個片段,C3a和C3b。C3a過敏毒素是局部炎癥過程的介質(zhì)。在慢性炎癥中,充當(dāng)中性粒細(xì)胞的化學(xué)引誘劑。激活后,C3b可以通過其反應(yīng)性硫酯與細(xì)胞表面碳水化合物或免疫聚集體共價結(jié)合。它誘導(dǎo)平滑肌收縮,增加血管通透性,并導(dǎo)致肥大細(xì)胞和嗜堿性白細(xì)胞釋放組胺。
Complement C3用戶評價
關(guān)鍵字: 補體C3;Complement C3;C3補體蛋白;CPAMD1;Complement C3蛋白;
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