GFR alpha-like產(chǎn)品信息
英文名稱:GDNF family receptor alpha-like
靶點別稱:GFR alpha like,GFR alpha-like,GFRAL,GRAL
物種:Human / Mouse / Cynomolgus / Rat
屬性:Protein / Antibody Licensing
標記:Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
GFR alpha-like分子背景
GFRα樣也稱為GDNF家族受體α樣、GFRAL、C6orf144、UNQ9356、PRO34128。生長分化因子-15(GDF15)是一種循環(huán)蛋白,與多種生物學(xué)過程有關(guān),包括能量穩(wěn)態(tài)、體重調(diào)節(jié)和癌癥和慢性病引起的惡病質(zhì)。GDNF家族受體α樣(GFRAL)最近被確定為負責介導(dǎo)GDF15厭食作用的神經(jīng)元腦干受體。GDF15的腦干限制性受體,在代謝和毒素誘導(dǎo)的壓力下調(diào)節(jié)食物攝入、能量消耗和體重。GDF15與其配體相互作用后,與RET相互作用,并通過激活MAPK和AKT信號通路誘導(dǎo)細胞信號傳導(dǎo)。
關(guān)鍵字: GFR alpha like;GFR alpha蛋白;GFRAL;GFRAL蛋白;GRAL;
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