Integrin αvβ1產(chǎn)品信息

英文名稱：Integrin alpha-V/beta-1

中文名稱：整合素α-V/β-1復(fù)合體

靶點(diǎn)別稱：Integrin αvβ1,Integrin alpha V beta 1,ITGAV&ITGB1

物種：Human / Cynomolgus / Rat

屬性：Protein

標(biāo)記：Biotin-labeled / Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH 8.0 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

Integrin αvβ1分子背景

整合素α-5/β-1是纖維蛋白原的受體。整合素α-1/β-1、α-2/β-1，α-6/β-1和α-7/β-1是lamimin的受體。整合素α-4/β-1是VCAM-1的受體。它識(shí)別VCAM-1中的序列Q-I-D-S。整合素α-9/β-1是VCAM-1、細(xì)胞觸覺(jué)素和骨橋蛋白的受體。它識(shí)別細(xì)胞觸覺(jué)素中的序列A-E-I-D-G-I-E-L。整合素α-V/β-1也是玻連蛋白的受體。Beta-1整合素在多種配體中識(shí)別R-G-D序列。異構(gòu)體2干擾異構(gòu)體1，對(duì)細(xì)胞粘附和遷移（體外）產(chǎn)生顯性負(fù)面影響。當(dāng)與α-7/β-1整合素結(jié)合時(shí)，調(diào)節(jié)細(xì)胞粘附和層粘連蛋白基質(zhì)沉積。