TNFSF11產(chǎn)品信息
英文名稱：Tumor necrosis factor ligand superfamily member 11
中文名稱：腫瘤壞死因子配體超家族成員11
靶點(diǎn)別稱：TNFSF11,RANKL,CD254,TRANCE,OPGL,ODF
物種：Human / Cynomolgus / Rat
屬性：Protein / Kits
標(biāo)記：Biotin-labeled / Unconjugated
內(nèi)毒素（Endotoxin）
Less than 0.1 EU per μg by the LAL method.
無(wú)菌（Sterility）
The sterility testing was performed by membrane filtration method.
純度（Purity）
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
制劑（Formulation）
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法（Reconstitution）
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)（Storage）
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
TNFSF11分子背景
Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is known as a type II membrane protein and is a member of the tumor necrosis factor (TNF) superfamily. RANKL, through its ability to stimulate osteoclast formation and activity, is a critical mediator of bone resorption and overall bone density. Some findings also suggestion some cancer cells, particularly prostate cancer cells, can activate an increase in bone remodeling and ultimately increase overall bone production.[17] This increase in bone remodeling and bone production increases the overall growth of bone metastasizes. The overall control of bone remodeling is regulated by the binding of RANKL with its receptor or its decoy receptor, respectively, RANK and OPG.
TNFSF11用戶評(píng)價(jià)
關(guān)鍵字： TNFSF11;TNFSF11蛋白;RANKL;CD254;RANKL蛋白;
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