Integrin alpha 4 beta 7產(chǎn)品信息

英文名稱(chēng)：Integrin alpha-4/beta-7

中文名稱(chēng)：整合素α-4/β-7復(fù)合體

靶點(diǎn)別稱(chēng)：Integrin alpha 4 beta 7,Integrin α4β7,Integrin a4b7

物種：Human

屬性：Protein

標(biāo)記：Unconjugated

蛋白結(jié)構(gòu)（Molecular Characterization） 

Human ITGA4&ITGB7 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA4 and ITGB7, has a calculated MW of 111.4 kDa (ITGA4) & 83.7 kDa (ITGB7). The protein migrates as 55 kDa, 80 kDa, 100-120 kDa and 130-150 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under non-reducing (NR) condition (SDS-PAGE) due to glycosylation.

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in 50 mM Tris, 150 mM NaCl, pH7.5 with trehalose as protectant.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

Integrin alpha 4 beta 7分子背景

整合素α4β7是一種整合素家族粘附受體，與α4β1（VLA4）和E-鈣粘蛋白受體αEβ7共享亞基。整合素α4β7對(duì)腸黏膜歸巢至關(guān)重要，在派爾氏結(jié)或腸系膜淋巴結(jié)的T細(xì)胞活化過(guò)程中被誘導(dǎo)。其表達(dá)需要來(lái)自局部樹(shù)突和基質(zhì)細(xì)胞的信號(hào)，包括分泌的視黃酸。HIV-1包膜蛋白gp120與整合素α4β7的活性形式結(jié)合，這可能解釋也可能不解釋腸道相關(guān)淋巴組織（GALT）中HIV-1病毒的濃度。整合素α4β7也可能參與急性腸移植物抗宿主病（GVHD）中的淋巴細(xì)胞運(yùn)輸。

Integrin alpha 4 beta 7用戶評(píng)價(jià)