IL-10產(chǎn)品信息

英文名稱：Interleukin-10

中文名稱：白細(xì)胞介素-10

靶點(diǎn)別稱：CSIF,IL-10,IL10A,TGIF,B-TCGF,GVHDS,MGC126450,MGC126451,RP11-262N9.1,Interleukin-10

物種：Human / Mouse / Cynomolgus

屬性：Protein / Kits / Licensing

標(biāo)記：Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>92% as determined by SDS-PAGE.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70°C for 3 months under sterile conditions after reconstitution.

IL-10分子背景

白細(xì)胞介素-10（IL-10）也稱為人類細(xì)胞因子合成抑制因子（CSIF），是一種抗炎細(xì)胞因子。IL-10是一種免疫抑制細(xì)胞因子，由多種哺乳動(dòng)物細(xì)胞類型產(chǎn)生，包括巨噬細(xì)胞、單核細(xì)胞、T細(xì)胞、B細(xì)胞和角質(zhì)形成細(xì)胞。成熟的人IL-10與牛、犬、馬、貓、小鼠、綿羊、豬和大鼠IL-10具有72%-86%的氨基酸序列同一性。雖然人IL-10對(duì)小鼠細(xì)胞有活性，但小鼠IL-10不作用于人細(xì)胞。IL-10能夠抑制巨噬細(xì)胞和調(diào)節(jié)性T細(xì)胞等細(xì)胞產(chǎn)生的促炎細(xì)胞因子如IFN-γ、IL-2、IL-3、TNFα和GM-CSF的合成。它還顯示出抑制抗原呈遞細(xì)胞抗原呈遞能力的強(qiáng)大能力。然而，它對(duì)某些T細(xì)胞和肥大細(xì)胞也有刺激作用，并刺激B細(xì)胞成熟和抗體產(chǎn)生。敲除研究表明，白細(xì)胞介素-10/IL-10在腸道中起著重要的免疫調(diào)節(jié)作用?？肆_恩病患者對(duì)使用產(chǎn)生重組白細(xì)胞介素-10的細(xì)菌進(jìn)行治療反應(yīng)良好，這表明白細(xì)胞介蛋白-10對(duì)抵消人體過度免疫的重要性。

IL-10用戶評(píng)價(jià)