Complement C5產(chǎn)品信息
英文名稱:Complement C5
中文名稱:補(bǔ)體C5
靶點(diǎn)別稱:Complement C5,CPAMD4
物種:Human / Mouse / Cynomolgus / Rat / Rabbit
屬性:Protein
標(biāo)記:Biotin-labeled / Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>90% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(chǔ)(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
Complement C5分子背景
C5過敏毒素來源于補(bǔ)體C5的蛋白水解降解,是局部炎癥過程的介質(zhì)。C5前體首先通過去除4個(gè)堿性殘基進(jìn)行加工,形成由二硫鍵連接的兩條鏈,β和α。C5轉(zhuǎn)化酶通過切割α鏈激活C5,釋放C5a過敏毒素并產(chǎn)生C5b(β鏈+α'鏈)。C5轉(zhuǎn)化酶激活C5啟動(dòng)晚期補(bǔ)體成分C5-C9自發(fā)組裝成膜攻擊復(fù)合物。C5b具有C6的瞬時(shí)結(jié)合位點(diǎn)。C5b-C6絡(luò)合物是裂解絡(luò)合物組裝的基礎(chǔ)。C5a過敏毒素與C5AR1和蜱補(bǔ)體抑制劑相互作用。C5a也是一種強(qiáng)效的趨化因子,可以刺激多形核白細(xì)胞的運(yùn)動(dòng),并引導(dǎo)它們向炎癥部位遷移。
Complement C5用戶評(píng)價(jià)
關(guān)鍵字: 補(bǔ)體C5;補(bǔ)體C5蛋白;Complement C5;C5補(bǔ)體;C5補(bǔ)體蛋白;
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