B7-H4產(chǎn)品信息
英文名稱:V-set domain-containing T-cell activation inhibitor 1
中文名稱:含V區(qū)域T細(xì)胞激活抑制因子1
靶點(diǎn)別稱:B7-H4,VTCN1,B7S1,B7h.5
物種:Human / Mouse / Cynomolgus / Rhesus macaque / Rat / Canine
屬性:Protein / Cell
標(biāo)記:Biotin-labeled / Unconjugated
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構(gòu)方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
B7-H4分子背景
含V集結(jié)構(gòu)域的T細(xì)胞活化抑制劑1(VTCN1)也稱為免疫共刺激蛋白B7-H4、蛋白B7S1、T細(xì)胞共刺激分子B7x、B7H4,屬于免疫球蛋白超家族和BTN/MOG家族。VTCN1含有兩個(gè)Ig樣V型(免疫球蛋白樣)結(jié)構(gòu)域。IL6和IL10上調(diào)VTCN1的表達(dá),GM-CSF和IL4抑制抗原呈遞細(xì)胞(APCs)上的VTCN1表達(dá)。VTCN1/B7-H4通過抑制T細(xì)胞活化、增殖、細(xì)胞因子產(chǎn)生和細(xì)胞毒性的發(fā)展,負(fù)調(diào)控T細(xì)胞介導(dǎo)的免疫反應(yīng)。VTCN1參與促進(jìn)上皮細(xì)胞轉(zhuǎn)化。
B7-H4用戶評價(jià)
關(guān)鍵字: B7-H4;B7-H4蛋白;B7H4;B7H4蛋白;B7-H4抗原;
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