FAP產(chǎn)品信息
英文名稱:Fibroblast activation protein alpha
中文名稱:成纖維細胞激活蛋白α
靶點別稱:FAP,FAP alpha,SIMP,Seprase,APCE
物種:Human / Mouse / Cynomolgus / Rat
屬性:Protein / Beads
標記:Biotin-labeled / FITC Labeled / Unconjugated / PE Labeled
內(nèi)毒素(Endotoxin)
Less than 1.0 EU per μg by the LAL method.
純度(Purity)
>95% as determined by SDS-PAGE.
>95% as determined by SEC-MALS.
制劑(Formulation)
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
Contact us for customized product form or formulation.
重構方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存儲(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
1. -20°C to -70°C for 12 months in lyophilized state;
2. -70°C for 3 months under sterile conditions after reconstitution.
FAP分子背景
FAP(也稱為seprase)是一種II型跨膜絲氨酸蛋白酶。質(zhì)膜和可溶性形式都表現(xiàn)出脯氨酸切割后的內(nèi)肽酶活性,對Ala/Ser-Gly-Pro-Ser/Asn/Ala共有序列有明顯的偏好。也降解明膠,熱變性I型膠原蛋白。還具有二肽基肽酶活性,優(yōu)選Ala-Pro、Ile-Pro、Gly-Pro、Arg-Pro和Pro-Pro。質(zhì)膜形式與DPP4、PLAUR或整合素結合,參與細胞外基質(zhì)(ECM)的細胞周蛋白水解,從而促進細胞通過ECM的粘附、遷移和侵襲。通過降解短鏈蛋白多糖促進膠質(zhì)瘤細胞通過腦實質(zhì)的侵襲。通過以絲氨酸蛋白酶活性無關的方式調(diào)節(jié)細胞增殖和存活,在黑素細胞中充當腫瘤抑制因子。
FAP用戶評價
關鍵字: FAP;FAP蛋白;FAP重組蛋白;成纖維細胞激活蛋白α;FAP alpha;
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