Fc gamma RIIA / CD32a信息

英文名稱：Low affinity immunoglobulin gamma Fc region receptor II-a

中文名稱：低親和力免疫球蛋白γFc區(qū)受體II-a

靶點(diǎn)別稱：CD32a，FCGR2A，CD32，FCG2，FCGR2A1，IGFR2

物種：Human / Cynomolgus / Rat / Rhesus macaque

屬性：Protein / Cell

標(biāo)記：Biotin-labeled / Unconjugated

內(nèi)毒素（Endotoxin）

Less than 1.0 EU per μg by the LAL method.

純度（Purity）

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制劑（Formulation）

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.

Contact us for customized product form or formulation.

重構(gòu)方法（Reconstitution）

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存儲(chǔ)（Storage）

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

1. -20°C to -70°C for 12 months in lyophilized state;

2. -70^°C for 12 months under sterile conditions after reconstitution.

Fc gamma RIIA / CD32a分子背景

IgG Fc區(qū)受體（FcγR）是Ig超家族的成員，在激活或抑制免疫反應(yīng)中發(fā)揮作用。識(shí)別出三類人FcγRs：RI（CD64）、RII（CD32）和RIII（CD16），它們產(chǎn)生多種亞型。人類FcγRII/CD32有三個(gè)基因（A、B和C），小鼠FcγRII B有一個(gè)基因（CD32B）。CD32是IgG的低親和力受體。激活亞型CD32A在單核細(xì)胞、中性粒細(xì)胞、血小板和樹(shù)突狀細(xì)胞上表達(dá)。CD32A在許多免疫細(xì)胞類型（巨噬細(xì)胞、中性粒細(xì)胞、嗜酸性粒細(xì)胞、血小板、樹(shù)突狀細(xì)胞和Langerhan細(xì)胞）上表達(dá)，其中攜帶抑制性ITIM的受體也可能與特定配體共表達(dá)和共結(jié)合。CD32A在配體結(jié)合時(shí)傳遞激活信號(hào)，并導(dǎo)致炎癥反應(yīng)的啟動(dòng)，包括細(xì)胞溶解、吞噬、脫顆粒和細(xì)胞因子的產(chǎn)生。反應(yīng)可以通過(guò)來(lái)自共表達(dá)的抑制性受體（如CD32B）的信號(hào)來(lái)調(diào)節(jié)，信號(hào)的強(qiáng)度取決于激活和抑制性受體的表達(dá)比率。

Fc gamma RIIA / CD32a產(chǎn)品用戶評(píng)價(jià)