中文名：Linezolid (PNU-100766)
英文名：Linezolid (PNU-100766)
英文別名：(S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
純度：10mM in DMSO
貨號(hào)：L408943
包裝：1ml
Cas號(hào)：165800-03-3
存儲(chǔ)溫度：-80℃儲(chǔ)存
產(chǎn)品介紹：
Information
Linezolid (PNU-100766) is a synthetic antibiotic used for the treatment of serious infections.
In?vitro
Linezolid inhibits initiation complex formation with either the 30S or the 70S ribosomal subunits from Escherichia coli. Linezolid inhibits complex formation with Staphylococcus aureus 70S tight-couple ribosomes. Linezolid is a potent inhibitor of cell-free transcription-translation in E. coli, exhibiting 50% inhibitory concentrations (IC50s) of 1.8 mM. Linezolid\xa0is an oxazolidinone, a new class of antibacterial agents with enhanced activity\xa0against\xa0pathogens. Linezolid MICs vary slightly with the test method, laboratory, and significance attributed to thin hazes of bacterial survival, but all workers find that the susceptibility distributions are narrow and unimodal, with MIC values between 0.5 and 4 mg/L for streptococci, enterococci and staphylococci. Linezolid entails mutation of the 23S rRNA that forms the binding site. Linezolid is an oxazolidinone whose mechanism of action involves inhibition of protein synthesis at a very early stage. Linezolid is added to 7H10 agar medium (Difco) supplemented with OADC (oleic acid, albumin, dextrose, and catalase) at 50°C to 56°C by doubling the dilutions to yield a final concentration of 0.125 μg/mL to 4 μg/mL. Linezolid shows excellent in vitro activity against all the strains tested (MICs ≤ 1 μg/ml), including those resistant to SIRE.
In?vivo
Cell?Data
cell?lines：U87, LN229, NIH3T3, HUVECs, BaF3 and TT thyroid carcinoma cells
Concentrations：
Incubation?Time：
Powder?Purity:≥99%
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關(guān)鍵字： (S)-N-((3-(3-fluoro-4-morpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
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