中文名：LIT-927

英文名：LIT-927

英文別名：LIT-927|2172879-52-4|4-(4-Chlorophenyl)-6-(4-hydroxy-3-methoxyphenyl)pyrimidin-2(1H)-one|LIT927|CHEMBL4166454|6-(4-chlorophenyl)-4-(4-hydroxy-3-methoxyphenyl)-1H-pyrimidin-2-one|SCHEMBL19782686|GTPL10075|LIT 927|DTXSID001162146|LIT 927; LIT927|BCP29866|EX

純度：99%

貨號：L414198

包裝：25mg、5mg、100mg

Cas號：2172879-52-4

存儲溫度：-20°C儲存

產(chǎn)品介紹：

Information

LIT-927 is a novel neutraligand ofCXCL12with Ki value of 267 nM for inhibition of Texas red-labeled CXCL12 (CXCL12-TR) binding. It shows high selectivity toward CXCL12 vs other chemokines also involved in asthma.

Targets

CXCR4 ; CXCL12 ; 267 nM(Ki)

In vitro

LIT-927 is able to bind selectively CXCL12 and to inhibit CXCL12-CXCR4 interaction.

In vivo

In a murine model of hypereosinophilia, LIT-927 shows a large and statistically reliable inhibition of eosinophil recruitment. It inhibits allergic eosinophilic airway inflammation in mice when administered orally or locally.

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