中文名：SU 16f,PDGFRβ抑制劑

英文名：SU 16f

中文別名：5-[1,2-二氫-2-氧代-6-苯基-3H-吲哚-3-亞甲基)甲基] -2,4-二甲基-1H-吡咯-3-丙酸

純度：≥98%(HPLC)

貨號：S288019

包裝：10mg、50mg、100mg

Cas號：251356-45-3

存儲溫度：避光,-20°C儲存

產(chǎn)品介紹：

產(chǎn)品介紹：
A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDGFR inhibitor (IC50 = 10 nM against PDGFRβ), while affecting Flk-1/KDR/ VEGFR2, FGFR1, and EGFR only at much higher concentrations (IC50 = 0.14, 2.29, and >100 μM, respectively). Reported to selectively inhibit PDGFβ- over EGF-stimulated proliferation in EGFR-expressing NIH 3T3 cultures (IC50 = 0.11 and 21.9 μM, respectively) and exhibit much weaker potency against the proliferation of HUVEC cells upon FGF or VEGF stimulation (IC50 = 10 μM).

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